New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.
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新的酒精相关基因表明与神经精神疾病有共同的遗传机制

DOI:
10.1038/s41562-019-0653-z
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发表时间:
2019-09
影响因子:
29.9
通讯作者:
Elliott P
Elliott P
中科院分区:
心理学1区
文献类型:
--
作者:
Evangelou E;Gao H;Chu C;Ntritsos G;Blakeley P;Butts AR;Pazoki R;Suzuki H;Koskeridis F;Yiorkas AM;Karaman I;Elliott J;Luo Q;Aeschbacher S;Bartz TM;Baumeister SE;Braund PS;Brown MR;Brody JA;Clarke TK;Dimou N;Faul JD;Homuth G;Jackson AU;Kentistou KA;Joshi PK;Lemaitre RN;Lind PA;Lyytikäinen LP;Mangino M;Milaneschi Y;Nelson CP;Nolte IM;Perälä MM;Polasek O;Porteous D;Ratliff SM;Smith JA;Stančáková A;Teumer A;Tuominen S;Thériault S;Vangipurapu J;Whitfield JB;Wood A;Yao J;Yu B;Zhao W;Arking DE;Auvinen J;Liu C;Männikkö M;Risch L;Rotter JI;Snieder H;Veijola J;Blakemore AI;Boehnke M;Campbell H;Conen D;Eriksson JG;Grabe HJ;Guo X;van der Harst P;Hartman CA;Hayward C;Heath AC;Jarvelin MR;Kähönen M;Kardia SLR;Kühne M;Kuusisto J;Laakso M;Lahti J;Lehtimäki T;McIntosh AM;Mohlke KL;Morrison AC;Martin NG;Oldehinkel AJ;Penninx BWJH;Psaty BM;Raitakari OT;Rudan I;Samani NJ;Scott LJ;Spector TD;Verweij N;Weir DR;Wilson JF;Levy D;Tzoulaki I;Bell JD;Matthews PM;Rothenfluh A;Desrivières S;Schumann G;Elliott P

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过量饮酒是世界范围内死亡和残疾的主要原因之一。饮酒是一种可遗传的复杂特征。我们对英国生物库、AlcGen和Charge+联合体中积累了480,842名欧洲血统的人进行了一项关于克/天(g/d)酒精消费的全基因组关联研究(GWAS)的荟萃分析,以破译酒精摄入的遗传结构。我们确定了46个新的、常见的基因座,并利用磁共振成像数据和基因表达研究来研究它们潜在的功能意义。我们的结果确定了与饮酒有关的遗传路径,并表明包括精神分裂症在内的神经精神疾病具有共同的遗传机制。
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a meta-analysis of genome-wide association studies (GWAS) of gram/day (g/d) alcohol consumption in UK-Biobank, AlcGen and CHARGE+ consortia accumulating 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigated their potential functional significance using magnetic resonance imaging data and gene expression studies. Our results identify genetic pathways associated with alcohol consumption and suggest shared genetic mechanisms with neuropsychiatric disorders including schizophrenia.
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