One-Pot Synthesis of Oxidation-Sensitive Supramolecular Gels and Vesicles.
One-Pot Synthesis of Oxidation-Sensitive Supramolecular Gels and Vesicles.
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DOI：
10.1021/acs.biomac.1c01039
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发表时间：
2021-12-13
影响因子：
6.2
通讯作者：
Battaglia G
中科院分区：
文献类型：
--
作者：
Duro-Castano A;Rodríguez-Arco L;Ruiz-Pérez L;De Pace C;Marchello G;Noble-Jesus C;Battaglia G
从纳米医学的角度来看，多肽基纳米颗粒具有独特的优势，如生物相容性、生物可降解性和对（病理）生理条件的刺激响应特性。传统的自组装多肽纳米结构的制备方法是先合成其组成的两亲性多肽，然后进行聚合后的自组装。在此，我们描述了氧化敏感的超分子胶束和囊泡的一锅合成。这是通过在二甲基亚砜（DMSO）中使用聚环氧乙烷作为稳定和亲水嵌段的n-羧基氢化物（NCA）前体的聚合诱导自组装（PISA）实现的。通过调整疏水块的长度和浓度，我们获得了从球形到蠕虫状胶束到囊泡的一系列形态。值得注意的是，多肽的二级结构极大地影响了组装体的最终形态。令人惊讶的是，虫状胶束形态适用于广泛的蛋氨酸块长度和固体含量，球形胶束仅限于非常短的疏水长度。虫状胶束在反应釜中进一步组装成氧化敏感的、独立的凝胶。用这种方法获得的囊泡和虫状胶束在受控的氧化条件下都可以降解，这将扩大它们在生物医学上的应用，如在持续药物释放或组织工程中的细胞支架中。
Polypeptide-based nanoparticles offer unique advantages from a nanomedicine perspective such as biocompatibility, biodegradability, and stimuli-responsive properties to (patho)physiological conditions. Conventionally, self-assembled polypeptide nanostructures are prepared by first synthesizing their constituent amphiphilic polypeptides followed by postpolymerization self-assembly. Herein, we describe the one-pot synthesis of oxidation-sensitive supramolecular micelles and vesicles. This was achieved by polymerization-induced self-assembly (PISA) of the N-carboxyanhydride (NCA) precursor of methionine using poly(ethylene oxide) as a stabilizing and hydrophilic block in dimethyl sulfoxide (DMSO). By adjusting the hydrophobic block length and concentration, we obtained a range of morphologies from spherical to wormlike micelles, to vesicles. Remarkably, the secondary structure of polypeptides greatly influenced the final morphology of the assemblies. Surprisingly, wormlike micellar morphologies were obtained for a wide range of methionine block lengths and solid contents, with spherical micelles restricted to very short hydrophobic lengths. Wormlike micelles further assembled into oxidation-sensitive, self-standing gels in the reaction pot. Both vesicles and wormlike micelles obtained using this method demonstrated to degrade under controlled oxidant conditions, which would expand their biomedical applications such as in sustained drug release or as cellular scaffolds in tissue engineering.
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影响因子：
7.015
作者：
Hill, Megan R.;Guegain, Elise;Sumerlin, Brent S.
通讯作者：
Sumerlin, Brent S.
DOI：
10.3390/antiox7010013
发表时间：
2018-01-16
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Ježek J;Cooper KF;Strich R
通讯作者：
Strich R
影响因子：
15
作者：
Battaglia, G;Ryan, AJ
通讯作者：
Ryan, AJ
影响因子：
2.7
作者：
Grogan, Joseph M.;Bau, Haim H.
通讯作者：
Bau, Haim H.
N-羧酸酐诱导自组装开环聚合制备可生物降解聚合物囊泡
影响因子：
7.015
作者：
Jiang, Jinhui;Zhang, Xinyue;Du, Jianzhong
通讯作者：
Du, Jianzhong