Reactive Oxygen Species and Mitochondrial Dynamics: The Yin and Yang of Mitochondrial Dysfunction and Cancer Progression.
Reactive Oxygen Species and Mitochondrial Dynamics: The Yin and Yang of Mitochondrial Dysfunction and Cancer Progression.
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DOI：
10.3390/antiox7010013
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发表时间：
2018-01-16
期刊：
影响因子：
--
通讯作者：
Strich R
中科院分区：
文献类型：
--
作者：
Ježek J;Cooper KF;Strich R
线粒体是具有高度动态超微结构的细胞器，其分裂和融合速率之间保持微妙的平衡。了解影响这种平衡的因素是重要的，因为线粒体动力学的扰动可能导致病理状态。作为细胞营养氧化的终点，线粒体发电站在电子传递链驱动的过程中以ATP的形式利用能量。同时，在电子传递链内易位的电子与氧发生自发的副反应，产生超氧化物和各种其他下游活性氧物质（ROS）。线粒体来源的ROS可以介导氧化还原信号，或者过量，导致细胞损伤甚至细胞死亡。最近的证据表明，线粒体超微结构是紧密耦合到ROS的产生取决于细胞的生理状态。然而，线粒体形状的变化调节线粒体功能和氧化还原稳态的机制尚不清楚。异常的线粒体形态可能导致增强的ROS形成，这反过来可能恶化线粒体健康并进一步加剧氧化应激，形成自我延续的恶性循环。在这里，我们回顾了线粒体动力学和ROS产生之间错综复杂的关系的最新研究结果，主要集中在其在恶性疾病中的作用。
Mitochondria are organelles with a highly dynamic ultrastructure maintained by a delicate equilibrium between its fission and fusion rates. Understanding the factors influencing this balance is important as perturbations to mitochondrial dynamics can result in pathological states. As a terminal site of nutrient oxidation for the cell, mitochondrial powerhouses harness energy in the form of ATP in a process driven by the electron transport chain. Contemporaneously, electrons translocated within the electron transport chain undergo spontaneous side reactions with oxygen, giving rise to superoxide and a variety of other downstream reactive oxygen species (ROS). Mitochondrially-derived ROS can mediate redox signaling or, in excess, cause cell injury and even cell death. Recent evidence suggests that mitochondrial ultrastructure is tightly coupled to ROS generation depending on the physiological status of the cell. Yet, the mechanism by which changes in mitochondrial shape modulate mitochondrial function and redox homeostasis is less clear. Aberrant mitochondrial morphology may lead to enhanced ROS formation, which, in turn, may deteriorate mitochondrial health and further exacerbate oxidative stress in a self-perpetuating vicious cycle. Here, we review the latest findings on the intricate relationship between mitochondrial dynamics and ROS production, focusing mainly on its role in malignant disease.
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