The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research.
The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research.
复制标题
DOI：
10.1111/bdi.12556
复制
发表时间：
2017-11
影响因子：
5.4
通讯作者：
Youngstrom EA
中科院分区：
文献类型：
--
作者：
Goldstein BI;Birmaher B;Carlson GA;DelBello MP;Findling RL;Fristad M;Kowatch RA;Miklowitz DJ;Nery FG;Perez-Algorta G;Van Meter A;Zeni CP;Correll CU;Kim HW;Wozniak J;Chang KD;Hillegers M;Youngstrom EA
在过去的二十年中，关于儿童和青少年双相情感障碍（BD）（即儿科BD [PBD]）的研究有了巨大的增长。本文的主要目的是提取现存文献，消除该领域的神话或夸张的断言，并传播临床相关发现。一个国际专家组完成了对文献的选择性审查，强调了共识领域，确定了文献中的局限性和差距，并强调了缩小这些差距的未来方向。关于PBD的现象学、鉴别诊断、病程、治疗和神经生物学的大量且日益国际化的研究已经积累。先前围绕易怒和筛查工具在诊断中的作用的分歧已经大大减弱。金标准药理学试验为躁狂/混合型发作的治疗提供了信息，而关于双相抑郁和维持/继续治疗的数据较少。辅助性心理社会治疗为心理教育提供了一个论坛，主要针对抑郁症状。大量的神经认知和神经影像学研究，以及越来越多的外周生物标志物研究，在很大程度上与BD成人的既往研究结果一致。随着数据的积累和争议的消散，该领域已经超越了关于PBD的存在问题，转向定义和追求仍然存在的紧迫的临床和科学优先事项。总体证据支持这样的观点，即关于显著的国际（美国与其他地方）和发育（儿科与成人）差异的看法被夸大了，尽管有必要对这些主题进行额外的研究。持续强调病理生理学和新疗法将支持对改善结局的牵引。
Over the past two decades, there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (ie, pediatric BD [PBD]). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions in the field, and disseminate clinically relevant findings. An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps. Substantial, and increasingly international, research has accumulated regarding the phenomenology, differential diagnosis, course, treatment, and neurobiology of PBD. Prior division around the role of irritability and of screening tools in diagnosis has largely abated. Gold‐standard pharmacologic trials inform treatment of manic/mixed episodes, whereas fewer data address bipolar depression and maintenance/continuation treatment. Adjunctive psychosocial treatment provides a forum for psychoeducation and targets primarily depressive symptoms. Numerous neurocognitive and neuroimaging studies, and increasing peripheral biomarker studies, largely converge with prior findings from adults with BD. As data have accumulated and controversy has dissipated, the field has moved past existential questions about PBD toward defining and pursuing pressing clinical and scientific priorities that remain. The overall body of evidence supports the position that perceptions about marked international (US vs elsewhere) and developmental (pediatric vs adult) differences have been overstated, although additional research on these topics is warranted. Traction toward improved outcomes will be supported by continued emphasis on pathophysiology and novel therapeutics.
登录
查看更多内容
影响因子：
6.4
作者：
Benarous X;Mikita N;Goodman R;Stringaris A
通讯作者：
Stringaris A
影响因子：
3.6
作者：
Althoff, Robert R.;Ayer, Lynsay A.;Rettew, David C.;Hudziak, James J.
通讯作者：
Hudziak, James J.
DOI：
10.1016/j.jaac.2010.10.007
发表时间：
2011-01-01
影响因子：
13.3
作者：
Caetano, Sheila C.;Olvera, Rene L.;Soares, Jair C.
通讯作者：
Soares, Jair C.
影响因子：
6.6
作者：
Brambilla, P;Stanley, JA;Soares, JC
通讯作者：
Soares, JC
影响因子：
3.8
作者：
Bauer, Mark S.;McBride, Linda;Sajatovic, Martha
通讯作者：
Sajatovic, Martha