Glycolipid‐Enriched Caveolae and Caveolae‐Like Domains in the Nervous System
Glycolipid‐Enriched Caveolae and Caveolae‐Like Domains in the Nervous System
复制标题
神经系统中富含糖脂的小凹和类小凹结构域
DOI：
10.1046/j.1471-4159.1999.0730001.x
复制
发表时间：
1999
影响因子：
4.7
通讯作者：
M. Pitto
中科院分区：
文献类型：
--
作者：
M. Masserini;P. Palestini;M. Pitto
翻译后摘要：近年来的特点是蓬勃发展的兴趣研究小窝和小窝样膜域。当假设它们参与基本的膜相关事件（如信号传递和脂质/蛋白质分选）时，对这一主题的兴趣进一步增长。在了解真核细胞膜结构域的生物学作用方面已经取得了实质性进展。然而，神经元可能是研究膜交通和功能的最大挑战之一，只进行了部分研究。本综述的目的是调查这个问题在神经系统。我们仅限于神经系统中膜结构域的存在，并在三个事实的背景下讨论这一点：首先，糖脂特别富集在小窝和小窝样结构域中，并且在神经系统中特别丰富;第二，神经元的特征在于基本的双极性，在这方面类似于其他极化细胞，其中富含糖脂的结构域在脂质/蛋白质分选中的作用已经得到了更好的确定;第三，神经元是从更简单的真核细胞进化而来的，并且与之相关，这使我们能够找到与更多研究的非神经元细胞的类比。
Abstract: Recent years have been characterized by a booming interest in research on caveolae and caveolae‐like membrane domains. The interest in this subject grew further, when their involvement in fundamental membrane‐associated events, such as signal transmission and lipid/protein sorting, was postulated. Substantial progress has been reached in understanding the biological role of membrane domains in eukaryotic cells. The neuron, however, which perhaps represents one of the greatest challenges to research on membrane traffic and function, has only been partially investigated. The purpose of the present review is to survey this issue in the nervous system. We confine ourselves to the presence of membrane domains in the nervous system and discuss this in the context of three facts: first, glycolipids are peculiarly enriched in both caveolae and caveolae‐like domains and are particularly abundant in the nervous system; second, the neuron is characterized by a basic dual polarity, similar in this respect to other polarized cells, where the role of glycolipid‐enriched domains for lipid/protein sorting has been better ascertained; and third, neurons evolved from, and are related to, simpler eukaryotic cells, allowing us to find analogies with more investigated nonneuronal cells.
登录
查看更多内容
影响因子：
3.5
作者：
Galbiati, F;Volonté, D;Lisanti, MP
通讯作者：
Lisanti, MP
DOI：
10.1073/pnas.92.20.9407
发表时间：
1995-09-26
影响因子：
11.1
作者：
SARGIACOMO, M;SCHERER, PE;LISANTI, MP
通讯作者：
LISANTI, MP
DOI：
10.1073/pnas.92.22.10104
发表时间：
1995-10-24
影响因子：
11.1
作者：
SMART, EJ;YING, YS;ANDERSON, RGW
通讯作者：
ANDERSON, RGW
DOI：
10.1073/pnas.91.25.12130
发表时间：
1994-12-06
影响因子：
11.1
作者：
SCHROEDER, R;LONDON, E;BROWN, D
通讯作者：
BROWN, D
DOI：
10.1073/pnas.95.17.10257
发表时间：
1998-08-18
影响因子：
11.1
作者：
Galbiati, F;Volonté, D;Lisanti, MP
通讯作者：
Lisanti, MP