No change of hyperleptinemia despite a decrease in insulin concentration in patients with chronic renal failure on a supplemented very low protein diet.
No change of hyperleptinemia despite a decrease in insulin concentration in patients with chronic renal failure on a supplemented very low protein diet.
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尽管补充极低蛋白质饮食的慢性肾功能衰竭患者的胰岛素浓度降低，但高瘦素血症没有变化。
DOI：
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发表时间：
2000
影响因子：
13.2
通讯作者：
M. Aparicio
中科院分区：
文献类型：
--
作者：
V. de Précigout;P. Chauveau;C. Delclaux;W. el Haggan;L. Baillet;N. Barthe;A. Gobinet;C. Combe;M. Aparicio
慢性肾功能衰竭（CRF）患者常伴有高瘦素血症，这是由于肾组织瘦素代谢不足和可能的瘦素产生增加所致，而瘦素产生增加又可能是CRF患者高胰岛素血症和促炎细胞因子水平升高所致。在CRF患者中观察到的高胰岛素血症和胰岛素抵抗在补充极低蛋白饮食（SVLPD）后得到改善。本研究的目的是确定SVLPD对CRF患者高胰岛素血症和胰岛素抵抗的纠正是否伴随着高瘦素血症的改善。13例患者在SVLPD治疗前和治疗后1年接受了研究，SVLPD提供0.3 g/kg/d蛋白质，补充氨基酸和酮类类似物。1年后，患者的高胰岛素血症（7.4 +/- 1.6对13.8 +/- 2 microU/mL，在饮食开始时; P：= 0.05）和胰岛素抵抗明显减少，而血清瘦素水平保持不变（16.1 +/- 4.7对19.1 +/- 7.4 ng/mL，在研究开始时; P：=不显著）。血清瘦素水平和体脂百分比之间的初始相关性在随访期间持续存在。胰岛素和瘦素水平之间或这两个参数的变化之间没有相关性。我们的研究表明，SVLPD对CRF患者高胰岛素血症和胰岛素抵抗的纠正并不伴随着高瘦素血症的改善，因此似乎不是碳水化合物代谢变化的结果。
Chronic renal failure (CRF) is often accompanied by hyperleptinemia caused by deficient renal metabolism of leptin and possibly increased leptin production, which in turn may result from the hyperinsulinemia and increased proinflammatory cytokine levels in patients with CRF. The hyperinsulinemia and insulin resistance observed in patients with CRF improve on supplemented very low protein diets (SVLPDs). The goal of our study is to determine whether the correction of hyperinsulinemia and insulin resistance in patients with CRF by SVLPDs is accompanied by improvement in hyperleptinemia. Thirteen patients were studied before and 1 year after following SVLPDs providing 0.3 g/kg/d of protein, supplemented with amino acids and ketoanalogues. After 1 year, patients showed markedly less hyperinsulinemia (7.4 +/- 1.6 versus 13.8 +/- 2 microU/mL at the start of diet; P: = 0.05) and insulin resistance, whereas serum leptin levels remained unchanged (16.1 +/- 4.7 versus 19.1 +/- 7.4 ng/mL at start of the study; P: = not significant). The initial correlation between serum leptin level and percentage of body fat persisted during follow-up. No correlation was found between insulin and leptin levels or between the variation of these two parameters during the study. Our study shows that the correction of hyperinsulinemia and insulin resistance in patients with CRF by SVLPDs is not accompanied by improvement in hyperleptinemia, which consequently does not appear to result from changes in carbohydrate metabolism.
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DOI：
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发表时间：
1998-06
期刊：
Journal of the American Society of Nephrology : JASN
影响因子：
--
作者：
K. Johansen;K. Mulligan;V. Tai;M. Schambelan
通讯作者：
K. Johansen;K. Mulligan;V. Tai;M. Schambelan
影响因子：
15.9
作者：
MCCALEB, ML;IZZO, MS;LOCKWOOD, DH
通讯作者：
LOCKWOOD, DH
影响因子：
15.9
作者：
Sinha, MK;Ohannesian, JP;Caro, JF
通讯作者：
Caro, JF
DOI：
--
发表时间：
1997-09
期刊：
Journal of the American Society of Nephrology : JASN
影响因子：
--
作者：
O. Heimbürger;Fredrik Lönnqvist;Anders Danielsson;Jorgen Nordenstrom;P. Stenvinkel
通讯作者：
O. Heimbürger;Fredrik Lönnqvist;Anders Danielsson;Jorgen Nordenstrom;P. Stenvinkel
儿童时期肾衰竭。
DOI：
--
发表时间：
1983
期刊：
Comprehensive therapy
影响因子：
--
作者：
Weiss,RA;Spitzer,A
通讯作者：
Spitzer,A