Alcoholic muscle disease: Features and mechanisms
Alcoholic muscle disease: Features and mechanisms
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酒精性肌肉疾病：特征和机制
DOI：
10.1002/path.1711730405
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
T. Peters
中科院分区：
文献类型：
--
作者：
V. Preedy;J. Salisbury;T. Peters
大约50%的慢性酒精滥用者患有酒精性肌肉疾病。慢性酒精性骨骼肌肌病的特征是II型纤维的选择性萎缩，因此高达20%的整个骨骼肌组织丢失。肌病的发病机制目前尚不清楚，但已描述了一种模型，其中采用各种解剖学上不同的骨骼肌来反映I型和II型纤维，即比目鱼肌和跖肌。在慢性研究中，大鼠被喂食含有乙醇或葡萄糖（对照）的营养完全的液体饮食长达6周。在急性研究中，给大鼠单次注射乙醇，并在2.5小时后检查蛋白质合成速率。结果表明，肌病是由于骨骼肌蛋白质合成缺陷。从这些研究中获得的信息增强了我们对骨骼肌疾病的理解，其特点是对厌氧纤维的优先影响，并应适用于其他毒性或代谢性肌病的疾病过程。
Approximately 50 per cent of all chronic alcohol misusers have alcoholic muscle disease. Chronic alcoholic skeletal muscle myopathy is characterized by a selective atrophy of type II fibres, so that up to 20 per cent of the entire skeletal musculature is lost. The pathogenetic mechanism for the myopathy is currently unknown but a model has been described in which various anatomically‐distinct skeletal muscles are employed to reflect type I and II fibres, i.e. the soleus and plantaris, respectively. In chronic studies, rats were fed nutritionally complete liquid diets containing either ethanol or glucose (controls) for up to 6 weeks. In acute studies, rats were given single boluses of ethanol and rates of protein synthesis were examined at 2.5 h. The results show that the myopathy is due to defective skeletal muscle protein synthesis. The information gained from these studies enhances our understanding of skeletal muscle diseases characterized by preferential effects on anaerobic fibres and should be applicable to disease processes in other toxic or metabolic myopathies.
小型猪长期饲喂乙醇可降低组织花生四烯酸浓度。
DOI：
10.1093/ajcn/56.3.467
发表时间：
1992
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Nakamura,MT;Tang,AB;Villanueva,J;Halsted,CH;Phinney,SD
通讯作者：
Phinney,SD
DOI：
10.1111/j.1530-0277.1986.tb05140.x
发表时间：
1986-10-01
影响因子：
3.2
作者：
LIEBER, CS;DECARLI, LM
通讯作者：
DECARLI, LM