RTKN-1/Rhotekin shields endosome-associated F-actin from disassembly to ensure endocytic recycling.
RTKN-1/Rhotekin shields endosome-associated F-actin from disassembly to ensure endocytic recycling.
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RTKN-1/Rhotekin 保护内体相关的 F-肌动蛋白免受分解,以确保内吞回收
DOI:
10.1083/jcb.202007149
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发表时间:
2021-05-03
期刊:
影响因子:
--
通讯作者:
Shi A
中科院分区:
文献类型:
--
作者:
Yan Y;Liu S;Hu C;Xie C;Zhao L;Wang S;Zhang W;Cheng Z;Gao J;Fu X;Yang Z;Wang X;Zhang J;Lin L;Shi A
Yan et al. identify C. elegans RTKN-1 as a novel endocytic recycling regulator that impedes UNC-60A/cofilin-mediated endosomal actin disassembly. Further evidence indicates that the self-binding capacity of RTKN-1 is indispensable for this functionality and SDPN-1/Syndapin acts to direct the proper residency of RTKN-1 in recycling endosomes.
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