Longitudinal variability in airway responsiveness in a population-based sample of children and young adults. Intrinsic and extrinsic contributing factors.
Longitudinal variability in airway responsiveness in a population-based sample of children and young adults. Intrinsic and extrinsic contributing factors.
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基于人群的儿童和年轻人样本中气道反应性的纵向变异。
DOI：
10.1164/ajrccm/140.1.172
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Weiss,ST
中科院分区：
文献类型：
--
作者：
Redline,S;Tager,IB;Speizer,FE;Rosner,B;Weiss,ST
对参加肺功能纵向研究的 287 名儿童和年轻人（23 岁）（735 次挑战测试）评估了气道对冷空气过度换气反应的程度和长期变异性，其中 179 名儿童在 1982 年至 1986 年间接受了 2 至 5 次冷空气挑战测试。响应（攻击后 FEV1 下降百分比）和二分结果的调整优势比（如果 FEV1 下降百分比约为 0.13，则为“阳性”）。研究了反应性变异与以下变量之间的关系：年龄、肺功能基线水平、呼吸道症状和疾病的存在、吸烟暴露、季节、测试期间达到的通气水平以及呼出空气的温度。在所有调查中，49 名曾表现出“积极”气道反应的受试者中，只有 6 名 (12%) 始终表现出气道高反应性。调查之间与气道高反应性相关的阳性反应的几率为 12.1，“持续”喘息为 21.5，“任何”喘息为 6.7。气道高反应性的显着预测因素是喘息症状 (OR= 2.3)、花粉症 (OR= 1.6) 和需要卧床休息的胸部疾病 (OR= 2.5)。不同调查之间呼吸道症状的差异，或者不同调查之间测试条件的差异，并没有改变观察到的气道反应性的变异性（通过对 21 名受试者的子样本进行气道反应性的重复测量进行评估），将观察到的调查间变异性提高了 30%。这些数据表明，在年轻、相对健康的人群中，气道反应性测试的结果可能会因调查而异。
The degree and long-term variability of airway responsiveness to eucapneic hyperventilation with cold air was assessed in 287 children and young adults «23 yr of age)(735 challenge tests) enrolled in a longitudinal study of pulmonary function, 179of whom underwent two to five cold-air challenge tests between 1982 and 1986. Survey-to-survey variability in airway responsiveness was assessed with computation of adjusted within-subject correlation coefficients for continuous measures of response (percent decrease in FEV, after challenge) and with adjusted odds ratios for dichotomous outcomes (" positive" if percent decrease FEV,~ 0.13). The relationships between variability in responsiveness and the following variables were examined: age, baseline level of pulmonary function, presence of respiratory symptoms and illnesses, smoking exposures, season, level of ventilation achieved during testing, and temperature of the expired air. Airway hyperresponsiveness was demonstrated consistently over all surveys in only six of 49 (12%) subjects who had ever demonstrated a" positive" airway response. The odds relating positive responses between surveys was 12.1 for airway hyperresponsiveness, 21.5 for" persistent" wheeze, and 6.7 for''any" wheeze. Significant predictors of airway hyperresponsiveness were wheeze symptoms (OR= 2.3), hay fever (OR= 1.6), and a chest illness requiring bed rest (OR= 2.5). Adjustment for survey-to-survey differences in respiratory symptoms, or for differences in testing conditions between surveys, did not alter the observed variability in airway responsiveness. Adjustment for" random error"(assessed with replicate measures of airway responsiveness in a subsample of 21 subjects) improved the observed survey-to-survey variability by 30%. These data suggest that in a young, relatively healthy population, results of tests of airway responsiveness may vary between surveys.
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冷空气诱发的哮喘及其与乙酰甲胆碱非特异性支气管反应的关系。
DOI：
--
发表时间：
2015
期刊：
American Review of Respiratory Disease
影响因子：
--
作者：
P. O'Byrne;G. Ryan;M. Morris;D. McCormack;N. Jones;J. Morse;F. Hargreave
通讯作者：
F. Hargreave
对吸入组胺反应的短期和长期重现性：Rt 与 FEV1 相比，作为对挑战反应的测量。
DOI：
--
发表时间：
1985
期刊：
European journal of respiratory diseases
影响因子：
--
作者：
F. Madsen;N. H. Rathlou;L. Frølund;U. Svendsen;B. Weeke
通讯作者：
B. Weeke
支气管哮喘特应性异常的β肾上腺素理论
DOI：
--
发表时间：
1968
期刊：
影响因子：
--
作者：
A. Szentivanyi
通讯作者：
A. Szentivanyi
气道炎症对于臭氧引起的高反应性的重要性。
DOI：
10.1164/arrd.1983.127.6.686
发表时间：
1983
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Holtzman,MJ;Fabbri,LM;O'Byrne,PM;Gold,BD;Aizawa,H;Walters,EH;Alpert,SE;Nadel,JA
通讯作者：
Nadel,JA
影响因子：
5
作者：
TAGER, IB;WEISS, ST;SPEIZER, FE
通讯作者：
SPEIZER, FE