Application of volumetric MR spectroscopic imaging for localization of neocortical epilepsy.
Application of volumetric MR spectroscopic imaging for localization of neocortical epilepsy.
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DOI：
10.1016/j.eplepsyres.2009.10.009
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发表时间：
2010-02
影响因子：
2.2
通讯作者：
Bowen, Brian C.
中科院分区：
文献类型：
--
作者：
Maudsley, Andrew A.;Domenig, Claudia;Ramsay, R. Eugene;Bowen, Brian C.
本研究的目的是评估体积质子磁共振波谱成像 (MRSI) 在新皮质癫痫中致癫痫病灶的定位。 25 名报告癫痫发作被认为是新皮质起源的受试者被招募参加一项 3-Tesla MR 研究，该研究包括高分辨率结构 MRI 和全脑 MRSI 采集。使用全自动 MRSI 处理协议，创建信号强度标准化 N-乙酰天冬氨酸 (NAA)、肌酸和胆碱图，以及每个 MRSI 体素内灰质、白质和脑脊液的相对体积分数。通过目视观察代谢物和代谢物比率图进行分析；基于体素计算这些代谢物图谱相对于正常对照的差异；每个脑叶体积的平均灰质和白质代谢物值的比较；以及按脑区检查相对左右不对称因素。来自十四名受试者的数据适合纳入分析。八名受试者患有 MRI 可见的病理，这些病理与 NAA/肌酸的减少有关，其范围超出了 MRI 指示的范围。使用任何分析方法，五名受试者均未表现出明显的代谢变化，一名受试者的 MRI 或 MRSI 没有发现任何结果。这项原理证明研究支持了先前的证据，即可以在受新皮质癫痫活动影响的组织区域中检测到 MR 检测到的脑代谢物的变化，同时还证明了体积 MRSI 方法的优势。
The aim of this study was to evaluate volumetric proton magnetic resonance spectroscopic imaging (MRSI) for localization of epileptogenic foci in neocortical epilepsy. Twenty-five subjects reporting seizures considered to be of neocortical origin were recruited to take part in a 3-Tesla MR study that included high-resolution structural MRI and a whole-brain MRSI acquisition. Using a fully-automated MRSI processing protocol, maps for signal-intensity normalized N-Acetylaspartate (NAA), creatine, and choline were created, together with the relative volume fraction of grey-matter, white-matter, and CSF within each MRSI voxel. Analyses were performed using visual observation of the metabolite and metabolite ratio maps; voxel-based calculation of differences in these metabolite maps relative to normal controls; comparison of average grey- and white-matter metabolite values over each lobar volume; and examination of relative left-right asymmetry factors by brain region. Data from fourteen subjects were suitable for inclusion in the analysis. Eight subjects had MRI-visible pathologies that were associated with decreases in NAA/Creatine, which extended beyond the volume indicated by the MRI. Five subjects demonstrated no significant metabolic alterations using any of the analysis methods, and one subject had no findings on MRI or MRSI. This proof of principle study supports previous evidence that alterations of MR-detected brain metabolites can be detected in tissue areas affected by neocortical seizure activity, while additionally demonstrating advantages of the volumetric MRSI approach.
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