c-Rel is Required for the Induction of pTregs in the Eye but Not in the Gut Mucosa.
c-Rel is Required for the Induction of pTregs in the Eye but Not in the Gut Mucosa.
复制标题
c-Rel 是在眼睛中诱导 pTreg 所必需的，但在肠道粘膜中则不需要
DOI：
10.3109/08820139.2016.1172639
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发表时间：
2016-11
影响因子：
2.8
通讯作者：
Ruan Q
中科院分区：
文献类型：
--
作者：
Wang T;Shi W;Fan T;Wan X;Chen YH;Ruan Q
调节性T （Treg）细胞在维持免疫稳态和预防自身免疫性疾病中发挥着不可或缺的作用。Foxp3的表达标志着祖细胞对Treg谱系的承诺。尽管NF-κB家族转录因子c-Rel在调节天然Treg细胞（ntreg）中的基本功能已经被确定，但c-Rel是否参与了外周血Treg细胞（ptreg）的体内生成，ptreg细胞是由胸腺外成熟的CD4+常规T细胞发育而来。我们试图通过使用可表达或不表达c-Rel的卵清蛋白特异性T细胞受体转基因小鼠在眼睛和肠道粘膜中诱导pTregs来回答这个问题。我们的研究结果表明，当免疫介导的炎症发生时，Tregs可以以c- rel依赖的方式在眼睛中诱导。然而，口服抗原给药后，c-Rel对于诱导肠道黏膜的pTregs是必不可少的。因此，c-Rel可能在不同器官中调控pTregs的发育中发挥不同的作用。
Regulatory T (Treg) cells play an integral role in maintaining immune homeostasis and preventing autoimmune diseases. Foxp3 expression marks the commitment of progenitor cells to the Treg lineage. Although the essential function of the NF-κB family transcription factor c-Rel in the regulation of natural Treg cells (nTregs) has been firmly established, little is known about whether c-Rel is involved in the in vivo generation of peripheral Treg cells (pTregs), which develop from mature CD4+ conventional T cells outside of the thymus. We sought to answer this question through the induction of pTregs in the eye and gut mucosa using ovalbumin-specific T cell receptor transgenic mice that do or do not express c-Rel. Our results showed that Tregs can be induced in the eye in a c-Rel-dependent manner when immune-mediated inflammation occurs. However, c-Rel is dispensable for the induction of pTregs in the gut mucosa after oral antigen administration. Thus, c-Rel may play distinct roles in regulating the development of pTregs in different organs.
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影响因子：
4.4
作者：
Denniston, Alastair K.;Kottoor, Sherine H.;Curnow, S. John
通讯作者：
Curnow, S. John
DOI：
10.1073/pnas.94.6.2642
发表时间：
1997-03-18
影响因子：
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作者：
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影响因子：
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作者：
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