Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa.
Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa.
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DOI：
10.1038/s41598-018-25645-9
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发表时间：
2018-05-08
影响因子：
4.6
通讯作者：
Wollstein G
中科院分区：
文献类型：
--
作者：
Wang B;Lucy KA;Schuman JS;Sigal IA;Bilonick RA;Lu C;Liu J;Grulkowski I;Nadler Z;Ishikawa H;Kagemann L;Fujimoto JG;Wollstein G
筛板是青光眼的主要损伤部位。虽然机械扭曲被假设会导致轴浆流量减少，但对于包含视网膜神经节细胞轴突的孔如何穿过筛板知之甚少。我们在体内研究了筛板孔路径，以量化健康和青光眼之间孔路径扭曲度的差异。我们使用扫描源光学相干断层扫描系统对来自70名受试者的16只健康眼睛、23只疑似青光眼和48只青光眼进行了成像。筛板孔隙使用先前描述的分割算法自动分割。使用定制软件自动跟踪筛网层深度的单个孔隙路径。每只眼睛的孔径收敛到视神经中枢和扭曲度被量化。我们发现，无论疾病严重程度或诊断类别如何，筛板孔通路沿着筛板深度穿过靠近视神经中枢的筛板。此外，青光眼的孔隙比健康眼在筛板上的通道更曲折，提示青光眼轴浆血流减少的潜在机制。
The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribrosa. We investigated lamina cribrosa pore paths in vivo to quantify differences in tortuosity of pore paths between healthy and glaucomatous eyes. We imaged 16 healthy, 23 glaucoma suspect and 48 glaucomatous eyes from 70 subjects using a swept source optical coherence tomography system. The lamina cribrosa pores were automatically segmented using a previously described segmentation algorithm. Individual pore paths were automatically tracked through the depth of the lamina cribrosa using custom software. Pore path convergence to the optic nerve center and tortuosity was quantified for each eye. We found that lamina cribrosa pore pathways traverse the lamina cribrosa closer to the optic nerve center along the depth of the lamina cribrosa regardless of disease severity or diagnostic category. In addition, pores of glaucoma eyes take a more tortuous path through the lamina cribrosa compared to those of healthy eyes, suggesting a potential mechanism for reduction of axoplasmic flow in glaucoma.
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影响因子：
3.4
作者：
Kraus MF;Potsaid B;Mayer MA;Bock R;Baumann B;Liu JJ;Hornegger J;Fujimoto JG
通讯作者：
Fujimoto JG
影响因子：
13.7
作者：
Park, Sung Chul;De Moraes, Carlos Gustavo V.;Ritch, Robert
通讯作者：
Ritch, Robert
影响因子：
4.1
作者：
Morgan, JE;Jeffery, G;Foss, AJE
通讯作者：
Foss, AJE
影响因子：
3.4
作者：
Nadler, Zach;Wang, Bo;Schuman, Joel S.
通讯作者：
Schuman, Joel S.
影响因子：
4.4
作者：
Akagi, Tadamichi;Hangai, Masanori;Yoshimura, Nagahisa
通讯作者：
Yoshimura, Nagahisa