The effects of low-impact mutations in digital organisms
The effects of low-impact mutations in digital organisms
复制标题
数字生物中低影响突变的影响
DOI：
--
复制
发表时间：
2011
影响因子：
--
通讯作者：
J. Sanford
中科院分区：
文献类型：
--
作者：
Chase W. Nelson;J. Sanford
背景Avida是一个计算机程序，它用数字生物进行进化实验。以前的工作已经使用该程序来研究复杂特征的进化起源，即逻辑运算，但一直使用非常大的突变适应度效应。本研究使用Avida，以更好地了解低影响的突变在evolution.ResultsWhen突变的健身效果约为0.075或更少的作用，没有新的逻辑操作进化，和那些以前进化的丢失。当健身效果约为0.2时，只有一半的操作进化，反映了选择崩溃的阈值。相比之下，当Avida的默认健身效果被使用，所有的操作例行演变到高频率和健身增加了平均20万，只有10，000 generations.ConclusionsAvidian生物进化新的逻辑操作时，只有当突变产生它们被分配高影响健身效果。此外，纯化选择不能保护具有低影响效益的操作免受突变恶化的影响。这些结果表明，低于一定的适应性效应（选择阈值）的低影响突变的选择失败。使用生物学相关参数设置的实验显示了增加遗传负荷导致生物学功能丧失的趋势。对这种遗传退化的理解与人类疾病有关，并且可能适用于通过使用致死诱变来控制病原体。
BackgroundAvida is a computer program that performs evolution experiments with digital organisms. Previous work has used the program to study the evolutionary origin of complex features, namely logic operations, but has consistently used extremely large mutational fitness effects. The present study uses Avida to better understand the role of low-impact mutations in evolution.ResultsWhen mutational fitness effects were approximately 0.075 or less, no new logic operations evolved, and those that had previously evolved were lost. When fitness effects were approximately 0.2, only half of the operations evolved, reflecting a threshold for selection breakdown. In contrast, when Avida's default fitness effects were used, all operations routinely evolved to high frequencies and fitness increased by an average of 20 million in only 10,000 generations.ConclusionsAvidian organisms evolve new logic operations only when mutations producing them are assigned high-impact fitness effects. Furthermore, purifying selection cannot protect operations with low-impact benefits from mutational deterioration. These results suggest that selection breaks down for low-impact mutations below a certain fitness effect, the selection threshold. Experiments using biologically relevant parameter settings show the tendency for increasing genetic load to lead to loss of biological functionality. An understanding of such genetic deterioration is relevant to human disease, and may be applicable to the control of pathogens by use of lethal mutagenesis.
影响因子：
3.1
作者：
LYNCH, M;BURGER, R;GABRIEL, W
通讯作者：
GABRIEL, W
DOI：
10.1098/rstb.2009.0266
发表时间：
2010-04-27
影响因子：
6.3
作者：
Keightley, Peter D.;Eyre-Walker, Adam
通讯作者：
Eyre-Walker, Adam