Subcortical brain atrophy persists even in HAART-regulated HIV disease.
Subcortical brain atrophy persists even in HAART-regulated HIV disease.
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DOI：
10.1007/s11682-011-9113-8
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发表时间：
2011-06
影响因子：
3.2
通讯作者：
Thompson, Paul M.
中科院分区：
文献类型：
--
作者：
Becker, James T.;Sanders, Joanne;Madsen, Sarah K.;Ragin, Ann;Kingsley, Lawrence;Maruca, Victoria;Cohen, Bruce;Goodkin, Karl;Martin, Eileen;Miller, Eric N.;Sacktor, Ned;Alger, Jeffery R.;Barker, Peter B.;Saharan, Priyanka;Carmichael, Owen T.;Thompson, Paul M.
本研究的目的是确定免疫状态和病毒复制控制良好的hiv感染男性尾状核和壳核萎缩的模式和程度。155名男性接受了结构脑磁共振成像；84名艾滋病毒感染者和71名未感染的对照组。MRI数据使用完全变形分割程序进行处理，生成左右尾状核和壳核的体积，以及厚度空间模式的三维地图。在艾滋病毒感染的男性中，尾状核和壳核都有明显的萎缩，主要是在前部。基底神经节的体积与首次血清阳性后的时间呈负相关，这表明要么存在一种慢性的亚临床过程，尽管治疗仍在继续，要么是初始损伤的程度导致了萎缩的程度。本文的在线版本（doi:10.1007/s11682-011- 91113 -8）包含补充资料，仅供授权用户使用。
The purpose of this study was to determine the pattern and extent of caudate nucleus and putamen atrophy in HIV-infected men with well-controlled immune status and viral replication. 155 men underwent structural brain magnetic resonance imaging; 84 were HIV-infected and 71 were uninfected controls. MRI data were processed using the Fully Deformable Segmentation routine, producing volumes for the right and left caudate nucleus and putamen, and 3-D maps of spatial patterns of thickness. There was significant atrophy in the HIV-infected men in both the caudate and putamen, principally in the anterior regions. The volume of the basal ganglia was inversely associated with the time since first seropositivity, suggesting that either there is a chronic, subclinical process that continues in spite of therapy, or that the extent of the initial insult caused the extent of atrophy. The online version of this article (doi:10.1007/s11682-011-9113-8) contains supplementary material, which is available to authorized users.
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影响因子：
9.9
作者：
Lin, JJ;Salamon, N;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
9.9
作者：
Childs, EA;Lyles, RH;McArthur, JC
通讯作者：
McArthur, JC
影响因子：
3.2
作者：
Cohen RA;Harezlak J;Schifitto G;Hana G;Clark U;Gongvatana A;Paul R;Taylor M;Thompson P;Alger J;Brown M;Zhong J;Campbell T;Singer E;Daar E;McMahon D;Tso Y;Yiannoutsos CT;Navia B
通讯作者：
Navia B
影响因子：
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作者：
Letendre, Scott;Marquie-Beck, Jennifer;Ellis, Ronald J.
通讯作者：
Ellis, Ronald J.
影响因子：
9.9
作者：
Becker, J. T.;Kingsley, L.;Visscher, B. R.
通讯作者：
Visscher, B. R.