Recommendations for Screening and Management of Late Effects in Patients with Severe Combined Immunodeficiency after Allogenic Hematopoietic Cell Transplantation: A Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric HCT.
Recommendations for Screening and Management of Late Effects in Patients with Severe Combined Immunodeficiency after Allogenic Hematopoietic Cell Transplantation: A Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric HCT.
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DOI：
10.1016/j.bbmt.2017.04.026
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Cowan MJ
中科院分区：
文献类型：
--
作者：
Heimall J;Buckley RH;Puck J;Fleisher TA;Gennery AR;Haddad E;Neven B;Slatter M;Roderick S;Baker KS;Dietz AC;Duncan C;Griffith LM;Notarangelo L;Pulsipher MA;Cowan MJ
严重联合免疫缺陷 (SCID) 可通过造血细胞移植 (HCT) 有效治疗，目前的报告显示总生存率接近 90%。然而，由于高质量免疫功能的持久性存在差异、SCID 的潜在基因型、移植前和移植后感染引起的合并症以及移植前的调理，幸存者面临出现晚期并发症的风险。 2016 年，一个国际移植专家小组召开会议，审查目前对 SCID 患者 HCT 后晚期效应的了解，并制定筛查和监测晚期效应的建议。本报告为接受 HCT 治疗的儿童和成人 SCID 患者的筛查和管理提供建议。
Severe combined immunodeficiency (SCID) is effectively treated with hematopoietic cell transplantation (HCT), with overall survival approaching 90% in contemporary reports. However, survivors are at risk for developing late complications because of the variable durability of high-quality immune function, underlying genotype of SCID, comorbidities due to infections in the pretransplantation and post-transplantation periods, and use of conditioning before transplantation. An international group of transplantation experts was convened in 2016 to review the current knowledge of late effects seen in SCID patients after HCT and to develop recommendations for screening and monitoring for late effects. This report provides recommendations for screening and management of pediatric and adult SCID patients treated with HCT.
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影响因子：
20.3
作者：
Neven, Benedicte;Leroy, Sandrine;Fischer, Alain
通讯作者：
Fischer, Alain
影响因子：
14.2
作者：
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通讯作者：
Landais, Paul
DOI：
10.1016/j.bbmt.2011.11.014
发表时间：
2012-01
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Bunin N;Small T;Szabolcs P;Baker KS;Pulsipher MA;Torgerson T
通讯作者：
Torgerson T
影响因子：
8.6
作者：
Orange, Jordan S.;Grossman, William J.;Wilkes, Mahlon M.
通讯作者：
Wilkes, Mahlon M.
DOI：
10.1016/j.jaci.2016.01.051
发表时间：
2016-08
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Griffith LM;Cowan MJ;Notarangelo LD;Kohn DB;Puck JM;Shearer WT;Burroughs LM;Torgerson TR;Decaluwe H;Haddad E;workshop participants
通讯作者：
workshop participants