External validity of a hierarchical dimensional model of child and adolescent psychopathology: Tests using confirmatory factor analyses and multivariate behavior genetic analyses.
External validity of a hierarchical dimensional model of child and adolescent psychopathology: Tests using confirmatory factor analyses and multivariate behavior genetic analyses.
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DOI：
10.1037/abn0000183
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发表时间：
2016-11
影响因子：
4.6
通讯作者：
Lahey BB
中科院分区：
文献类型：
--
作者：
Waldman ID;Poore HE;van Hulle C;Rathouz PJ;Lahey BB
最近几项关于精神病理学层次表型结构的研究已经在青年和成人样本中除了更预期的具体外化和内化维度之外还确定了一般精神病理学因素，并且一些研究发现了该一般因素的相关独特外部关联。我们使用来自 1,568 对 9-17 岁双胞胎（599 MZ 和 969 DZ）的数据来检验青少年精神病理学基本结构的假设以及高阶因素的外部有效性。通过对看护者和青少年进行结构化访谈来评估精神病理学症状。我们使用验证性因素分析对竞争结构模型进行表型分析，并使用结构方程模型和多元行为遗传分析来了解高阶因素的病因及其外部有效性。我们发现，一般因素以及特定的外化和内化维度对于在表型和病因学水平上表征青年精神病理学都是必要的，并且三个高阶因素在其潜在遗传和环境影响的程度方面存在很大差异。从表型上看，当包含一般因素时，特定的外化和内化维度略有负相关，这反映了非共享环境（但不是遗传）对内化和外化的影响之间存在显着的负相关。我们首次估计了精神病理学一般因素的遗传力。它的中等遗传力表明它不仅仅是测量误差的产物，而且是一个有效的结构。一般因素、外化因素和内化因素与三个外部效度标准的关系有所不同：母亲在怀孕期间吸烟、父母的严厉管教以及青少年与不良同龄人的交往。多变量行为遗传分析通过表明一般因素、外化因素和内化因素与同侪犯罪和父母因不同病因的严厉管教相关而支持了三个高阶因素的外部效度。在这项研究中，我们通过检查与各种相关因素以及遗传和环境影响的差异关联，建立了儿童和青少年精神病理学分层维度模型的外部效度。
Several recent studies of the hierarchical phenotypic structure of psychopathology have identified a General psychopathology factor in addition to the more expected specific Externalizing and Internalizing dimensions in both youth and adult samples and some have found relevant unique external correlates of this General factor. We used data from 1,568 twin pairs (599 MZ & 969 DZ) age 9–17 to test hypotheses for the underlying structure of youth psychopathology and the external validity of the higher-order factors. Psychopathology symptoms were assessed via structured interviews of caretakers and youth. We conducted phenotypic analyses of competing structural models using Confirmatory Factor Analysis and used Structural Equation Modeling and multivariate behavior genetic analyses to understand the etiology of the higher-order factors and their external validity. We found that both a General factor and specific Externalizing and Internalizing dimensions are necessary for characterizing youth psychopathology at both the phenotypic and etiologic levels, and that the three higher-order factors differed substantially in the magnitudes of their underlying genetic and environmental influences. Phenotypically, the specific Externalizing and Internalizing dimensions were slightly negatively correlated when a General factor was included, which reflected a significant inverse correlation between the non-shared environmental (but not genetic) influences on Internalizing and Externalizing. We estimated heritability of the general factor of psychopathology for the first time. Its moderate heritability suggests that it is not merely an artifact of measurement error but a valid construct. The General, Externalizing, and Internalizing factors differed in their relations with three external validity criteria: mother’s smoking during pregnancy, parent’s harsh discipline, and the youth’s association with delinquent peers. Multivariate behavior genetic analyses supported the external validity of the three higher-order factors by suggesting that the General, Externalizing, and Internalizing factors were correlated with peer delinquency and parent’s harsh discipline for different etiologic reasons.. In this study we established the external validity of a hierarchical dimensional model of child and adolescent psychopathology by examining differential associations with various correlates and with genetic and environmental influences.
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DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
DOI：
10.1097/00004583-199607000-00011
发表时间：
1996-07-01
影响因子：
13.3
作者：
Lahey, BB;Flagg, EW;Regier, DA
通讯作者：
Regier, DA
影响因子：
2.6
作者：
Markon, KE;Krueger, RF
通讯作者：
Krueger, RF
DOI：
10.1097/00004583-199504000-00017
发表时间：
1995-04-01
影响因子：
13.3
作者：
LOEBER, R;GREEN, SM;LAHEY, BB
通讯作者：
LAHEY, BB
影响因子：
3.6
作者：
Olino, Thomas M.;Dougherty, Lea R.;Klein, Daniel N.
通讯作者：
Klein, Daniel N.