Inverse modeling framework for characterizing patient-specific microstructural changes in the pulmonary arteries.
Inverse modeling framework for characterizing patient-specific microstructural changes in the pulmonary arteries.
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DOI：
10.1016/j.jmbbm.2021.104448
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发表时间：
2021-07
影响因子：
3.9
通讯作者：
Lee, Lik-Chuan
中科院分区：
文献类型：
--
作者：
Pourmodheji, Reza;Jiang, Zhenxiang;Tossas-Betancourt, Christopher;Figueroa, C. Alberto;Baek, Seungik;Lee, Lik-Chuan
关键词：
与肺动脉高压（PAH）相关的肺动脉微观结构变化在人类中尚未得到充分了解和表征。为了解决这个问题，我们开发并应用了患者特定的逆有限元 (FE) 建模框架，利用体内压力测量和磁共振图像来表征近端肺动脉中微成分的机械和结构变化。该框架使用从一名儿科 PAH 患者和一名肺动脉压正常的心脏移植患者（作为对照）获得的数据进行应用。对与弹性蛋白、胶原纤维和平滑肌细胞的结构和机械性能相关的约束混合模型的参数进行优化，以适应患者特定的主肺动脉压力直径反应。基于优化的参数，估计了肺动脉中三种组织成分的个体应力和线性刚度合成值以及它们的聚合值。 PAH 患者的总应力和刚度分别是对照受试者的 4.6 倍和 3.4 倍。 PAH 患者中各组织成分的应力和僵硬度也较高。具体而言，PAH 患者和对照受试者的平均应力结果在弹性蛋白（PAH：69.96，对照：14.42 kPa-mm）中最高，其次是平滑肌细胞（PAH：13.95，对照：4.016 kPa-mm）和胶原纤维（PAH：13.19，对照：2.908 kPa-mm）。这一结果表明，弹性蛋白可能是 PAH 患者和对照受试者肺动脉中的关键承重成分。
Microstructural changes in the pulmonary arteries associated with pulmonary arterial hypertension (PAH) is not well understood and characterized in humans. To address this issue, we developed and applied a patient-specific inverse finite element (FE) modeling framework to characterize mechanical and structural changes of the micro-constituents in the proximal pulmonary arteries using in-vivo pressure measurements and magnetic resonance images. The framework was applied using data acquired from a pediatric PAH patient and a heart transplant patient with normal pulmonary arterial pressure, which serves as control. Parameters of a constrained mixture model that are associated with the structure and mechanical properties of elastin, collagen fibers and smooth muscle cells were optimized to fit the patient-specific pressure-diameter responses of the main pulmonary artery. Based on the optimized parameters, individual stress and linearized stiffness resultants of the three tissue constituents, as well as their aggregated values, were estimated in the pulmonary artery. Aggregated stress resultant and stiffness are, respectively, 4.6 and 3.4 times higher in the PAH patient than the control subject. Stress and stiffness resultants of each tissue constituent are also higher in the PAH patient. Specifically, the mean stress resultant is highest in elastin (PAH: 69.96, control: 14.42 kPa-mm), followed by those in smooth muscle cell (PAH: 13.95, control: 4.016 kPa-mm) and collagen fibers (PAH: 13.19, control: 2.908 kPa-mm) in both the PAH patient and the control subject. This result implies that elastin may be the key load-bearing constituent in the pulmonary arteries of the PAH patient and the control subject.
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影响因子：
2
作者：
Holzapfel, GA;Gasser, TC;Ogden, RW
通讯作者：
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影响因子：
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10.1142/s0218202502001714
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DOI：
10.1002/cnm.2982
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2018-07
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