Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication.
Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication.
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修饰的离子病毒Ankara可以在病毒复制的早期阶段，通过双链RNA激活蛋白激酶（PKR）依赖性途径激活NF-kappab转录因子。
DOI：
10.1016/j.virol.2009.06.012
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发表时间：
2009-09-01
期刊：
影响因子：
3.7
通讯作者：
Pickup, David J.
中科院分区：
文献类型：
--
作者：
Lynch, Heather E.;Ray, Caroline A.;Oie, Katrina L.;Pollara, Justin J.;Petty, Ian T. D.;Sadler, Anthony J.;Williams, Bryan R. G.;Pickup, David J.
Modified vaccinia virus Ankara (MVA), which is a promising replication-defective vaccine vector, is unusual among the orthopoxviruses in activating NF-κB transcription factors in cells of several types. In human embryonic kidney (HEK 293T) cells, the MVA-induced depletion of IκBα required to activate NF-κB is inhibited by UV-inactivation of the virus, and begins before viral DNA replication. In HEK 293T, CHO, or RK13 cells, expression of the cowpox virus CP77 early gene, or the vaccinia virus K1L early gene suppresses MVA-induced IκBα depletion. In mouse embryonic fibroblasts (MEFs), MVA induction of IκBα depletion is dependent on the expression of mouse or human double-stranded RNA-activated protein kinase (PKR). These results demonstrate that events during the early phase of MVA replication can induce PKR-mediated processes contributing both to the activation of NF-κB signaling, and to processes that may restrict viral replication. This property may contribute to the efficacy of this vaccine virus.
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DOI：
10.1073/pnas.89.11.4825
发表时间：
1992-06-01
影响因子：
11.1
作者：
CHANG, HW;WATSON, JC;JACOBS, BL
通讯作者：
JACOBS, BL
影响因子：
5.4
作者：
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通讯作者：
Shisler, Joanna L.
影响因子：
5.4
作者：
DAVIES, MV;ELROYSTEIN, O;KAUFMAN, RJ
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KAUFMAN, RJ
影响因子：
3.7
作者：
Carroll, MW;Moss, B
通讯作者：
Moss, B
影响因子：
5.4
作者：
Gallego-Gómez, JC;Risco, C;Esteban, M
通讯作者：
Esteban, M