Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence.
Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence.
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非典型蛋白激酶 C 亚型 (aPKCλ) 对于维持毛囊干细胞静止至关重要。
DOI：
10.1038/jid.2015.222
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Ohno S
中科院分区：
文献类型：
--
作者：
Osada S;Minematsu N;Oda F;Akimoto K;Kawana S;Ohno S
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The atypical protein kinase C (aPKC)-partition-defective (PAR) complex regulates the formation of tight junctions and apico-basal epithelial polarity. To examine the role of this complex in the epidermis, we generated mutant mice harboring epidermal-specific deletion of aPKCλ (conditional knock-out (cKO)), a major component of the aPKC-PAR complex. The mutant mice exhibited abnormal hair follicle (HF) cycling, progressive losses of pelage hairs and vibrissae, and altered differentiation into the epidermis and sebaceous gland. We found that in the aPKCλ cKO mice HF stem cell (HFSC) quiescence was lost, as revealed by the decreased expression level of quiescence-inducing factors (Fgf18 and Bmp6) produced in Keratin 6–positive bulge stem cells. The loss of quiescence dysregulated the HFSC marker expression and led to the increase in Lrig1-positive cells, inducing hyperplasia of the interfollicular epidermis and sebaceous glands, and drove an increase in Lef1-positive matrix cells, causing a prolonged anagen-like phase. Persistent bulge stem cell activation led to a gradual depletion of CD34- and α6 integrin–positive HFSC reservoirs. These results suggest that aPKCλ regulates signaling pathways implicated in HFSC quiescence.
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DOI：
10.1083/jcb.201307001
发表时间：
2013-09-16
期刊：
The Journal of cell biology
影响因子：
--
作者：
Niessen MT;Scott J;Zielinski JG;Vorhagen S;Sotiropoulou PA;Blanpain C;Leitges M;Niessen CM
通讯作者：
Niessen CM
影响因子：
23.9
作者：
Nowak JA;Polak L;Pasolli HA;Fuchs E
通讯作者：
Fuchs E
影响因子：
4.6
作者：
Jennifer L. Watts;Bijan Etemad-Moghadam;Su Guo;Lynn Boyd;Bruce W. Draper;Craig C. Mello;J. Priess;K. Kemphues
通讯作者：
Jennifer L. Watts;Bijan Etemad-Moghadam;Su Guo;Lynn Boyd;Bruce W. Draper;Craig C. Mello;J. Priess;K. Kemphues
影响因子：
23.9
作者：
Greco V;Chen T;Rendl M;Schober M;Pasolli HA;Stokes N;Dela Cruz-Racelis J;Fuchs E
通讯作者：
Fuchs E
非典型蛋白激酶 C 与 PAR-3 合作建立秀丽隐杆线虫的胚胎极性。
DOI：
10.1242/dev.125.18.3607
发表时间：
1998
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Tabuse,Y;Izumi,Y;Piano,F;Kemphues,KJ;Miwa,J;Ohno,S
通讯作者：
Ohno,S