A two-step mechanism for stem cell activation during hair regeneration.
A two-step mechanism for stem cell activation during hair regeneration.
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DOI：
10.1016/j.stem.2008.12.009
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发表时间：
2009-02-06
期刊：
影响因子：
23.9
通讯作者：
Fuchs E
中科院分区：
文献类型：
--
作者：
Greco V;Chen T;Rendl M;Schober M;Pasolli HA;Stokes N;Dela Cruz-Racelis J;Fuchs E
毛囊（HF）经历退化、静止和再生的周期性发作。在休息期间（休止期），毛胚（HG）表现为缓慢循环的凸起和真皮乳头（DP）之间的小细胞簇。在这里，我们表明，HG细胞来自隆突干细胞（SC），但变得更快地响应DP促进信号。在体外，HG细胞也增殖更快，但显示较短的寿命比隆突细胞的潜力。在分子上，它们更类似于激活的隆突细胞，而不是传递放大（基质）细胞。转录谱揭示了HG和DP在晚期休止期的早熟活性，伴随着HG中的Wnt信号传导和DP中升高的FGF和BMP抑制剂。FGF和BMP抑制剂参与Wnt在体内和体外对HG施加选择性和有效的刺激。我们的研究结果提出了一个模型，其中HG细胞为毛发再生的初始步骤提供燃料，而凸起是维持该过程的引擎。
Hair follicles (HFs) undergo cyclic bouts of degeneration, rest, and regeneration. During rest (telogen), the hair germ (HG) appears as a small cell cluster between the slow-cycling bulge and dermal papilla (DP). Here we show that HG cells are derived from bulge stem cells (SCs) but become responsive quicker to DP-promoting signals. In vitro, HG cells also proliferate sooner but display shorter-lived potential than bulge cells. Molecularly, they more closely resemble activated bulge rather than transit-amplifying (matrix) cells. Transcriptional profiling reveals precocious activity of both HG and DP in late telogen, accompanied by Wnt signaling in HG and elevated FGFs and BMP inhibitors in DP. FGFs and BMP inhibitors participate with Wnts in exerting selective and potent stimuli to the HG both in vivo and in vitro. Our findings suggest a model where HG cells fuel initial steps in hair regeneration, while the bulge is the engine maintaining the process.
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