Prefrontal Cortex Stimulation Enhances Fear Extinction Memory in Humans.
Prefrontal Cortex Stimulation Enhances Fear Extinction Memory in Humans.
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DOI：
10.1016/j.biopsych.2017.10.022
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发表时间：
2018-07-15
影响因子：
10.6
通讯作者：
Milad MR
中科院分区：
文献类型：
--
作者：
Raij T;Nummenmaa A;Marin MF;Porter D;Furtak S;Setsompop K;Milad MR
动物恐惧条件反射研究已经阐明了感觉刺激和恐惧反应之间习得联系的神经机制。在大鼠中，短暂的电刺激下缘(IL)皮质已被证明在回忆消失性记忆时减少了条件性冻结。在这里，我们通过MRI导航的经颅磁刺激(TMS)将这一发现翻译到人类身上。受试者(N=28)平均被限制于两种不同的线索(第1天)。在消亡学习(第二天)中，TMS与条件线索中的一个配对，而不与另一个配对。TMS参数与大鼠IL相似：短脉冲串(300ms，20 Hz)在提示开始后100ms开始，共4串(28个TMS脉冲)。TMS被应用于左额叶皮质的两个靶点之一，一个功能相连(靶1)，另一个不相连(靶2，对照)，与人在腹内侧额前皮质(VmPFC)的IL同源物(VmPFC)相连。皮肤电导反应(SCR)被用作条件性恐惧的指标。在消退回忆中(第3天)，与目标1的TMS配对的线索显示显著降低的SCR，而与目标2的TMS不起作用。此外，我们构建了组级别的地图，其中加权了TMS诱发的电场和扩散MRI连接性估计，并考虑了恐惧水平。这些地图显示了明显的大脑皮层区域和大规模网络，这些网络与恐惧的减少和增加有关。结果表明，时空聚焦的TMS可以增强消退学习和/或消退记忆的巩固，并为未来的研究提供新的皮质区域和大规模网络的靶向。
Animal fear conditioning studies have illuminated neuronal mechanisms of learned associations between sensory stimuli and fear responses. In rats, brief electrical stimulation of the infralimbic (IL) cortex has been shown to reduce conditioned freezing during recall of extinction memory. Here, we translate this finding to humans with MRI-navigated transcranial magnetic stimulation (TMS). Subjects (N=28) were aversively conditioned to two different cues (day 1). During extinction learning (day 2), TMS was paired with one of the conditioned cues but not the other. TMS parameters were similar to those used in rat IL: brief pulse trains (300 ms at 20 Hz) starting 100ms after cue onset, total of 4 trains (28 TMS pulses). TMS was applied to one of two targets in the left frontal cortex, one functionally connected (Target 1) and the other unconnected (Target 2, control) with a human homologue of IL in the ventromedial prefrontal cortex (vmPFC). Skin conductance responses (SCRs) were used as an index of conditioned fear. During extinction recall (day 3), the cue paired with TMS to Target 1 showed significantly reduced SCRs, whereas TMS to Target 2 had no effect. Further, we built group-level maps that weighted TMS-induced electric fields and diffusion MRI connectivity estimates with fear level. These maps revealed distinct cortical regions and large-scale networks associated with reduced vs. increased fear. The results show that spatiotemporally focused TMS may enhance extinction learning and/or consolidation of extinction memory, and suggest novel cortical areas and large-scale networks for targeting in future studies.
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DOI：
10.4088/jcp.08m04638blu
发表时间：
2010-08
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Boggio PS;Rocha M;Oliveira MO;Fecteau S;Cohen RB;Campanhã C;Ferreira-Santos E;Meleiro A;Corchs F;Zaghi S;Pascual-Leone A;Fregni F
通讯作者：
Fregni F
影响因子：
5.7
作者：
Fox MD;Liu H;Pascual-Leone A
通讯作者：
Pascual-Leone A
影响因子：
16.6
作者：
Ahveninen, Jyrki;Huang, Samantha;Nummenmaa, Aapo;Belliveau, John W.;Hung, An-Yi;Jaaskelainen, Iiro P.;Rauschecker, Josef P.;Rossi, Stephanie;Tiitinen, Hannu;Raij, Tommi
通讯作者：
Raij, Tommi
影响因子：
25
作者：
Burgos-Robles A;Kimchi EY;Izadmehr EM;Porzenheim MJ;Ramos-Guasp WA;Nieh EH;Felix-Ortiz AC;Namburi P;Leppla CA;Presbrey KN;Anandalingam KK;Pagan-Rivera PA;Anahtar M;Beyeler A;Tye KM
通讯作者：
Tye KM
影响因子：
7.7
作者：
Herrmann, Martin J.;Katzorke, Andrea;Deckert, Juergen
通讯作者：
Deckert, Juergen