Vaccines against drug abuse.
Vaccines against drug abuse.
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DOI:
10.1038/clpt.2011.281
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发表时间:
2012-01
影响因子:
6.7
通讯作者:
Kosten, T. R.
中科院分区:
文献类型:
--
作者:
Shen, X. Y.;Orson, F. M.;Kosten, T. R.
Current medications for drug abuse have had only limited success. Anti-addiction vaccines to elicit antibodies that block the pharmacological effects of drugs have great potential for treating drug abuse. We review the status for two vaccines that are undergoing clinical trials (cocaine and nicotine) and two that are still in pre-clinical development (methamphetamine and heroin). We also outline the challenges and ethical concerns for anti-addiction vaccine development and their use as future therapeutics.
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