Vaccines against drug abuse.

Vaccines against drug abuse.
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DOI:
10.1038/clpt.2011.281
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发表时间:
2012-01
影响因子:
6.7
通讯作者:
Kosten, T. R.
Kosten, T. R.
中科院分区:
医学2区
文献类型:
--
作者:
Shen, X. Y.;Orson, F. M.;Kosten, T. R.

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目前的药物治疗药物滥用只取得了有限的成功。抗成瘾疫苗可引发抗体,阻断药物的药理作用,具有治疗药物滥用的巨大潜力。我们回顾了两种正在进行临床试验的疫苗(可卡因和尼古丁)和两种仍处于临床前开发阶段的疫苗(甲基苯丙胺和海洛因)的现状。我们还概述了抗成瘾疫苗开发及其作为未来疗法的挑战和伦理问题。
Current medications for drug abuse have had only limited success. Anti-addiction vaccines to elicit antibodies that block the pharmacological effects of drugs have great potential for treating drug abuse. We review the status for two vaccines that are undergoing clinical trials (cocaine and nicotine) and two that are still in pre-clinical development (methamphetamine and heroin). We also outline the challenges and ethical concerns for anti-addiction vaccine development and their use as future therapeutics.
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