4-D flow magnetic resonance imaging: blood flow quantification compared to 2-D phase-contrast magnetic resonance imaging and Doppler echocardiography.
4-D flow magnetic resonance imaging: blood flow quantification compared to 2-D phase-contrast magnetic resonance imaging and Doppler echocardiography.
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DOI：
10.1007/s00247-014-3246-z
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发表时间：
2015-06
影响因子：
2.3
通讯作者：
Rigsby, Cynthia K.
中科院分区：
文献类型：
--
作者：
Gabbour, Maya;Schnell, Susanne;Jarvis, Kelly;Robinson, Joshua D.;Markl, Michael;Rigsby, Cynthia K.
关键词：
多普勒超声心动图(ECHO)是血流速度分析的参考标准，二维(2-D)相位对比磁共振成像(MRI)被认为是定量血流评估的参考标准。然而，这两种临床护理标准技术都受到二维采集和单向速度编码的限制，可能使它们不足以评估先天性心脏病所见的复杂的三维血流动力学。四维Flow MRI(4-D Flow)能够定性和定量分析心脏和大动脉中的复杂血流。本研究的目的是比较4-D血流和2-D相位对比MRI对主动脉和肺血流的定量，并评价基于4-D血流的容量血流分析相对于2-D相位对比MRI和ECHO在评估儿童和年轻人峰值速度方面的优势。对50例患者(平均年龄13.1±6.4岁)进行了主动脉根部、主肺动脉(MPA)、左、右肺动脉(RPA、LPA)的二维相位对比MRI扫描，并对主动脉和肺动脉进行了容积覆盖的四维血流成像。四维流分析包括计算净流量和回流分数，其中四维流分析平面的位置类似于二维平面。此外，我们还进行了主动脉根部/升主动脉的4-D血流容量测量，并与二维相位对比MRI和ECHO进行了比较。磁共振2-D相位对比图与4-D血流图显示的净血流量有很好的相关性和一致性(r=0.97P<；0.001)，返流分数的相关性也很好(r=0.88，P<；0.001)。与ECHO相比，二维相衬磁共振成像显著低估了主动脉(P=0.032)和Mpa(P<；0.001)的峰值速度，而容量四维血流分析显示相对于ECHO的峰值速度更高(P=0.001)或相近(Mpa：P=0.98)。2-D相位对比MRI与4-D Flow血流参数的良好一致性，以及相对于ECHO改进的体积4-D血流速度分析，表明4-D Flow有可能成为2-D相位对比MRI的临床替代方法。
Doppler echocardiography (echo) is the reference standard for blood flow velocity analysis, and two-dimensional (2-D) phase-contrast magnetic resonance imaging (MRI) is considered the reference standard for quantitative blood flow assessment. However, both clinical standard-of-care techniques are limited by 2-D acquisitions and single-direction velocity encoding and may make them inadequate to assess the complex three-dimensional hemodynamics seen in congenital heart disease. Four-dimensional flow MRI (4-D flow) enables qualitative and quantitative analysis of complex blood flow in the heart and great arteries. The objectives of this study are to compare 4-D flow with 2-D phase-contrast MRI for quantification of aortic and pulmonary flow and to evaluate the advantage of 4-D flow-based volumetric flow analysis compared to 2-D phase-contrast MRI and echo for peak velocity assessment in children and young adults. Two-dimensional phase-contrast MRI of the aortic root, main pulmonary artery (MPA), and right and left pulmonary arteries (RPA, LPA) and 4-D flow with volumetric coverage of the aorta and pulmonary arteries were performed in 50 patients (mean age: 13.1±6.4 years). Four-dimensional flow analyses included calculation of net flow and regurgitant fraction with 4-D flow analysis planes similarly positioned to 2-D planes. In addition, 4-D flow volumetric assessment of aortic root/ascending aorta and MPA peak velocities was performed and compared to 2-D phase-contrast MRI and echo. Excellent correlation and agreement were found between 2-D phase-contrast MRI and 4-D flow for net flow (r=0.97, P<0.001) and excellent correlation with good agreement was found for regurgitant fraction (r= 0.88, P<0.001) in all vessels. Two-dimensional phase-contrast MRI significantly underestimated aortic (P= 0.032) and MPA (P<0.001) peak velocities compared to echo, while volumetric 4-D flow analysis resulted in higher (aortic: P=0.001) or similar (MPA: P=0.98) peak velocities relative to echo. Excellent flow parameter agreement between 2-D phase-contrast MRI and 4-D flow and the improved volumetric 4-D flow velocity analysis relative to echo suggests that 4-D flow has the potential to become a clinical alternative to 2-D phase-contrast MRI.
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影响因子：
6.7
作者：
Frydrychowicz, Alex;Markl, Michael;Arnold, Raoul
通讯作者：
Arnold, Raoul
影响因子：
4.4
作者：
Markl, Michael;Harloff, Andreas;Frydrychowicz, Alex
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Frydrychowicz, Alex
DOI：
10.1177/108925320601000107
发表时间：
2006-03-01
影响因子：
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De Hert, Stefan G.
DOI：
10.1016/s1064-9689(02)00024-7
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2003-02-01
影响因子：
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Didier, Dominique
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影响因子：
4.4
作者：
Markl, Michael;Geiger, Julia;Arnold, Raoul
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