Granulocytes act as a niche for Mycobacterium tuberculosis growth.
Granulocytes act as a niche for Mycobacterium tuberculosis growth.
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DOI：
10.1038/s41385-020-0300-z
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发表时间：
2021-01
影响因子：
8
通讯作者：
Sassetti CM
中科院分区：
文献类型：
--
作者：
Lovewell RR;Baer CE;Mishra BB;Smith CM;Sassetti CM
Granulocyte recruitment to the pulmonary compartment is a hallmark of progressive tuberculosis (TB). This process is well-documented to promote immunopathology, but can also enhance the replication of the pathogen. Both the specific granulocytes responsible for increasing mycobacterial burden and the underlying mechanisms remain obscure. We report that the known immunomodulatory effects of these cells, such as suppression of protective T-cell responses, play a limited role in altering host control of mycobacterial replication in susceptible mice. Instead, we find that the adaptive immune response preferentially restricts the burden of bacteria within monocytes and macrophages compared to granulocytes. Specifically, mycobacteria within inflammatory lesions are preferentially found within long-lived granulocytes that express intermediate levels of the Ly6G marker and low levels of antimicrobial genes. These cells progressively accumulate in the lung and correlate with bacterial load and disease severity, and the ablation of Ly6G-expressing cells lowers mycobacterial burden. These observations suggest a model in which dysregulated granulocytic influx promotes disease by creating a permissive intracellular niche for mycobacterial growth and persistence.
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影响因子：
3.1
作者：
Liu Y;Nonnemacher MR;Wigdahl B
通讯作者：
Wigdahl B
DOI：
10.1084/jem.20161621
发表时间：
2017-05-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Deniset JF;Surewaard BG;Lee WY;Kubes P
通讯作者：
Kubes P
影响因子：
4.6
作者：
Lyadova IV
通讯作者：
Lyadova IV
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
5.4
作者：
Dorhoi, Anca;Yeremeev, Vladimir;Kaufmann, Stefan H. E.
通讯作者：
Kaufmann, Stefan H. E.