The Epithelial-to-Mesenchymal Transition in Breast Cancer: Focus on Basal-Like Carcinomas.
The Epithelial-to-Mesenchymal Transition in Breast Cancer: Focus on Basal-Like Carcinomas.
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DOI：
10.3390/cancers9100134
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发表时间：
2017-09-30
期刊：
影响因子：
5.2
通讯作者：
Chiappetta G
中科院分区：
文献类型：
--
作者：
Fedele M;Cerchia L;Chiappetta G
乳腺癌是一种异质性疾病，其特征在于由多种因素的贡献引起的高度细胞可塑性。当结合时，这些因素允许癌细胞通过去分化过程从上皮状态转变为间充质状态，该去分化过程赋予干细胞样特征，包括化学抗性，以及迁移和侵入的能力。因此，了解导致获得间充质表型的复杂事件将有助于设计针对转移性乳腺癌的新疗法。在这里，我们概括了参与这一过程的主要内源性分子信号，以及它们与旁分泌因子的相互作用。这些信号和串扰包括细胞外基质;癌症相关成纤维细胞、巨噬细胞、癌症干细胞和癌细胞的分泌体;以及具有其运载物miRNA的外来体。最后，我们强调了一些更有前途的治疗前景的基础上抵消乳腺癌细胞的上皮间质转化。
Breast cancer is a heterogeneous disease that is characterized by a high grade of cell plasticity arising from the contribution of a diverse range of factors. When combined, these factors allow a cancer cell to transition from an epithelial to a mesenchymal state through a process of dedifferentiation that confers stem-like features, including chemoresistance, as well as the capacity to migrate and invade. Understanding the complex events that lead to the acquisition of a mesenchymal phenotype will therefore help to design new therapies against metastatic breast cancer. Here, we recapitulate the main endogenous molecular signals involved in this process, and their cross-talk with paracrine factors. These signals and cross-talk include the extracellular matrix; the secretome of cancer-associated fibroblasts, macrophages, cancer stem cells, and cancer cells; and exosomes with their cargo of miRNAs. Finally, we highlight some of the more promising therapeutic perspectives based on counteracting the epithelial-to-mesenchymal transition in breast cancer cells.
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