The efficiency of the human CD8+ T cell response: how should we quantify it, what determines it, and does it matter?
The efficiency of the human CD8+ T cell response: how should we quantify it, what determines it, and does it matter?
复制标题
人CD8+ T细胞响应的效率:我们应该如何量化它,什么决定它,这有关系?
DOI:
10.1371/journal.pcbi.1002381
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发表时间:
2012
影响因子:
4.3
通讯作者:
Asquith B
中科院分区:
文献类型:
--
作者:
Elemans M;Seich Al Basatena NK;Asquith B
Multidisciplinary techniques, in particular the combination of theoretical and experimental immunology, can address questions about human immunity that cannot be answered by other means. From the turnover of virus-infected cells in vivo, to rates of thymic production and HLA class I epitope prediction, theoretical techniques provide a unique insight to supplement experimental approaches. Here we present our opinion, with examples, of some of the ways in which mathematics has contributed in our field of interest: the efficiency of the human CD8+ T cell response to persistent viruses.
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