Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia.
Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia.
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DOI：
10.1111/j.1349-7006.2001.tb02151.x
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发表时间：
2001-12
期刊：
影响因子：
--
通讯作者：
Matsuyama T
中科院分区：
文献类型：
--
作者：
Imaizumi Y;Kohno T;Yamada Y;Ikeda S;Tanaka Y;Tomonaga M;Matsuyama T
干扰素调节因子 (IRF) 4 是有丝分裂原激活的 T 细胞增殖所需的淋巴特异性转录因子。 IRF4 被认为参与肿瘤发生，因为 IRF4 的过度表达导致体外 Rat-1 成纤维细胞的转化。在这里，我们发现IRF4在成人T细胞白血病（ATL）衍生的细胞系中组成型表达，这些细胞系感染了人类T细胞白血病病毒I型，但几乎不表达反式激活蛋白Tax。同样，IRF4 的组成型表达在急性或慢性 ATL 患者新鲜分离的外周血单核细胞 (PBMC) 中得到证实。然而，IRF4 的高水平表达与急性 ATL 特异性相关。对于来自健康供体的有丝分裂原激活的 PBMC，细胞周期分析显示 IRF4 的诱导发生在细胞周期进展之前，并且进入细胞周期的细胞主要是 IRF4 阳性细胞。此外，Rat-1成纤维细胞中IRF4的异位表达显着增加了S期和G2/M期群体。综上所述，我们的结果表明IRF4通过其对细胞周期的积极作用参与ATL的发病机制，并且IRF4可以用作ATL临床亚型的分子标记。
Interferon regulatory factor (IRF) 4 is the lymphoid‐specific transcription factor that is required for the proliferation of mitogen‐activated T cells. IRF4 has been suggested to be involved in tuniorigenesis because the overexpression of IRF4 caused the transformation of Rat‐1 fibroblasts in vitro. Here, we show that IRF4 is constitutively expressed in adult T‐cell leukemia (ATL)‐derived cell lines, which were infected with human T‐cell leukemia virus type‐I, but hardly expressed the trans‐activator protein, Tax. Similarly, constitutive expression of IRF4 was demonstrated in freshly isolated peripheral blood mononuclear cells (PBMC) from patients with either acute or chronic ATL. However, the high‐level expression of IRF4 was specifically associated with acute ATL. With mitogen‐activated PBMC from healthy donors, cell cycle analyses revealed that the induction of IRF4 occurred prior to cell cycle progression and the cells that had entered the cell cycle were predominantly IRF4‐positive cells. In addition, ectopic expression of IRF4 in Rat‐1 fibroblasts increased the S and G2/M phase population significantly. Taken together, our results indicate that IRF4 is involved in the pathogenesis of ATL through its positive effect on the cell cycle, and that IRF4 can be used as a molecular marker of clinical subtype in ATL.
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RER诱导干扰素调节因子4（IRF-4）在淋巴细胞中的表达：通过REL/核因子Kappab对干扰素调节的基因表达的调节。
影响因子：
15.3
作者：
Grumont, R J;Gerondakis, S
通讯作者：
Gerondakis, S
影响因子：
3.9
作者：
Harada, H;Taniguchi, T;Tanaka, N
通讯作者：
Tanaka, N
DOI：
10.1073/pnas.77.12.7415
发表时间：
1980-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
POIESZ, BJ;RUSCETTI, FW;GALLO, RC
通讯作者：
GALLO, RC
影响因子：
20.3
作者：
Mori, N;Nunokawa, Y;Yamamoto, N
通讯作者：
Yamamoto, N
影响因子：
2.2
作者：
Douglas, RS;Tarshis, AD;Moore, JS
通讯作者：
Moore, JS