Gender-medicine aspects in allergology.
Gender-medicine aspects in allergology.
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DOI：
10.1111/j.1398-9995.2008.01645.x
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发表时间：
2008-05
期刊：
影响因子：
12.4
通讯作者：
Untersmayr E
中科院分区：
文献类型：
--
作者：
Jensen-Jarolim E;Untersmayr E
尽管相同的免疫机制激活释放介质和连续的症状，在立即型过敏，仍然有一个明确的临床差异，女性和男性过敏患者。尽管男孩在童年时期患过敏症的风险更大，但几乎从青春期开始，就特应性疾病而言，女性似乎是一个明显的劣势。哮喘、食物过敏和过敏反应在女性中更常见。反过来，哮喘和花粉热与月经不调有关。指出性激素的作用，哮喘和避孕药的摄入量的关联，以及怀孕期间哮喘恶化的风险已经被观察到。此外，据报告，绝经期和绝经后妇女越来越多地患有哮喘、气喘和花粉热，激素替代疗法甚至加剧了这种情况。这可能是由于最近发现的雌激素受体依赖性肥大细胞激活。作为一种自然的悖论，女性甚至可能对自己的性激素过敏，导致皮内注射雌激素或孕酮时出现阳性反应。更重要的是，这种特异性超敏反应与反复流产有关。尽管在IgE介导的过敏性疾病中存在显着的性别特异性偏见，但当今公众对这一事实的认识仍然很少。
Despite the identical immunological mechanisms activating the release of mediators and consecutive symptoms in immediate-type allergy, there is still a clear clinical difference between female and male allergic patients. Even though the risk of being allergic is greater for boys in childhood, almost from adolescence onwards it seems to be a clear disadvantage to be a woman as far as atopic disorders are concerned. Asthma, food allergies and anaphylaxis are more frequently diagnosed in females. In turn, asthma and hay fever are associated with irregular menstruation. Pointing towards a role of sex hormones, an association of asthma and intake of contraceptives, and a risk for asthma exacerbations during pregnancy have been observed. Moreover, peri- and postmenopausal women were reported to increasingly suffer from asthma, wheeze and hay fever, being even enhanced by hormone replacement therapy. This may be on account of the recently identified oestradiol-receptor-dependent mast-cell activation. As a paradox of nature, women may even become hypersensitive against their own sex hormones, resulting in positive reactivity upon intradermal injection of oestrogen or progesterone. More importantly, this specific hypersensitivity is associated with recurrent miscarriages. Even though there is a striking gender-specific bias in IgE-mediated allergic diseases, public awareness of this fact still remains minimal today.
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影响因子：
14.2
作者：
Dijkstra, A;Howard, TD;Postma, DS
通讯作者：
Postma, DS
影响因子：
1.9
作者：
Binkley, KE;Davis, AE
通讯作者：
Davis, AE
影响因子：
14.2
作者：
Geiger, E;Magerstaedt, R;Bieber, T
通讯作者：
Bieber, T
影响因子：
3.3
作者：
Benyamini, Y;Leventhal, EA;Leventhal, H
通讯作者：
Leventhal, H
DOI：
10.1196/annals.1386.043
发表时间：
2006-01-01
期刊：
ESTROGENS AND HUMAN DISEASES
影响因子：
--
作者：
Cutolo, Maurizio;Capellino, Silvia;Straubb, Rawer H.
通讯作者：
Straubb, Rawer H.