Primate malarias as a model for cross-species parasite transmission.
Primate malarias as a model for cross-species parasite transmission.
复制标题
灵长类动物疟疾作为跨物种寄生虫传播的模型。
DOI：
10.7554/elife.69628
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发表时间：
2022-01-28
期刊：
影响因子：
7.7
通讯作者：
Goldberg A
中科院分区：
文献类型：
--
作者：
Voinson M;Nunn CL;Goldberg A
寄生虫经常转换到新的宿主物种，这对宿主造成了疾病负担和保护风险。这些寄生虫的分布也提供了深入了解生态网络的特点和宿主-寄生虫相互作用的遗传机制。一些寄生虫在许多物种中共享，而另一些则倾向于仅限于单一物种的宿主。了解产生这种宿主特异性分布的机制可以实现更有效的干预措施，并可能确定疫苗或治疗的遗传靶点。随着人类和当地动物种群之间的生态联系的增加，新型寄生虫对人类和野生动物健康的风险也在增加。这些寄生虫中哪些会消失，哪些有可能在人类中广泛传播？我们考虑的情况下，灵长类动物疟疾，引起疟原虫寄生虫，调查相互作用的生态和进化机制，使人类和非人类灵长类动物感染的风险。疟原虫宿主从非人类灵长类动物转移到人类，导致了当今人类最常见的疟疾病原体的古老引入，新的寄生虫转移是一个日益增长的威胁，特别是在亚洲和南美洲。基于一个野生宿主疟原虫发生数据库，我们强调关注的地理区域和潜在的区域，以进一步采样为目标。我们还讨论了方法的发展，这将有利于临床和实地干预，以改善人类和野生动物的健康，基于这种生态进化的角度。
Parasites regularly switch into new host species, representing a disease burden and conservation risk to the hosts. The distribution of these parasites also gives insight into characteristics of ecological networks and genetic mechanisms of host-parasite interactions. Some parasites are shared across many species, whereas others tend to be restricted to hosts from a single species. Understanding the mechanisms producing this distribution of host specificity can enable more effective interventions and potentially identify genetic targets for vaccines or therapies. As ecological connections between human and local animal populations increase, the risk to human and wildlife health from novel parasites also increases. Which of these parasites will fizzle out and which have the potential to become widespread in humans? We consider the case of primate malarias, caused by Plasmodium parasites, to investigate the interacting ecological and evolutionary mechanisms that put human and nonhuman primates at risk for infection. Plasmodium host switching from nonhuman primates to humans led to ancient introductions of the most common malaria-causing agents in humans today, and new parasite switching is a growing threat, especially in Asia and South America. Based on a wild host-Plasmodium occurrence database, we highlight geographic areas of concern and potential areas to target further sampling. We also discuss methodological developments that will facilitate clinical and field-based interventions to improve human and wildlife health based on this eco-evolutionary perspective.
疟原虫，疟原虫相关的疟疾寄生虫：达菲结合蛋白II的遗传变异性和趋化因子的Duffy抗原/受体。
影响因子：
3.7
作者：
Camargos Costa D;Pereira de Assis GM;de Souza Silva FA;Araújo FC;de Souza Junior JC;Braga Hirano ZM;Satiko Kano F;Nóbrega de Sousa T;Carvalho LH;Ferreira Alves de Brito C
通讯作者：
Ferreira Alves de Brito C