B cells in multiple sclerosis: connecting the dots.
B cells in multiple sclerosis: connecting the dots.
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DOI：
10.1016/j.coi.2011.09.003
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发表时间：
2011-12
影响因子：
7
通讯作者：
Zamvil SS
中科院分区：
文献类型：
--
作者：
von Büdingen HC;Bar-Or A;Zamvil SS
Over the last two decades B cells have increasingly moved into the spotlight in multiple sclerosis (MS) research. This interest was fuelled by growing understanding and acceptance of pathological involvement of B cells and antibodies in MS. Data derived from animal models of MS, human histopathological studies, and analyses of B cells in the peripheral blood and cerebrospinal fluid (CSF) have permitted the integration of B cells in our overall picture of MS immunopathogenesis. The as yet strongest direct evidence for a central role of B cells in MS autoimmunity was the demonstration that peripheral B cell depletion leads to a rapid decline of disease-activity in MS. While lending formidable impact to peripheral blood B cells as mediators of disease activity, the effects of anti-CD20 treatment also seemingly challenged the paradigm of a role of antibodies in targeted central nervous system (CNS) myelin destruction. This review shall attempt to provide an overview of our current understanding of B cell and antibody mediated mechanisms relevant to MS. We will include findings from, both, human studies, and animal models to highlight the complexity of B cell function as it pertains to MS. B cells appear to be effective drivers of inflammatory activity in MS by way of a diverse toolset of cellular functions. These functions appear to be closely linked to B cells that can be found in the periphery. However, by serving as the source of antibodies, B cells offer a direct humoral response that may target the CNS and lead to tissue specific destruction. Therefore, B cells participate in MS pathogenesis on both sides of the blood-brain barrier.
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影响因子：
15.9
作者：
Cepok, S;Zhou, D;Hemmer, B
通讯作者：
Hemmer, B
影响因子：
5.4
作者：
Harp, Christopher T.;Ireland, Sara;Davis, Laurie S.;Remington, Gina;Cassidy, Bonnie;Cravens, Petra D.;Stuve, Olaf;Lovett-Racke, Amy E.;Eagar, Todd N.;Greenberg, Benjamin M.;Racke, Michael K.;Cowell, Lindsay G.;Karandikar, Nitin J.;Frohman, Elliot M.;Monson, Nancy L.
通讯作者：
Monson, Nancy L.
影响因子：
11.2
作者：
Barnett, Michael H.;Parratt, John D. E.;Prineas, John W.
通讯作者：
Prineas, John W.
DOI：
10.1056/nejmoa0706383
发表时间：
2008-02-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hauser, Stephen L;Waubant, Emmanuelle;Smith, Craig H
通讯作者：
Smith, Craig H
影响因子：
11.2
作者：
Brilot, Fabienne;Dale, Russell C.;Hemmer, Bernhard
通讯作者：
Hemmer, Bernhard