Suicide ideation and associated mortality in adult survivors of childhood cancer.
Suicide ideation and associated mortality in adult survivors of childhood cancer.
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DOI：
10.1002/cncr.28385
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发表时间：
2014-01-15
期刊：
影响因子：
6.2
通讯作者：
Krull, Kevin R.
中科院分区：
文献类型：
--
作者：
Brinkman, Tara M.;Zhang, Nan;Recklitis, Christopher J.;Kimberg, Cara;Zeltzer, Lonnie K.;Muriel, Anna C.;Stovall, Marilyn;Srivastava, Deo Kumar;Sklar, Charles A.;Robison, Leslie L.;Krull, Kevin R.
儿童期癌症的成年幸存者有自杀意念的风险，尽管自杀意念的纵向模式和复发率尚不清楚。我们调查了儿童癌症成年幸存者中迟报（即初次评估后）和复发性自杀意念的流行程度，确定了自杀意念的预测因素，并检查了自杀意念与死亡率之间的关系。参与者包括9,128名成年儿童癌症幸存者和3,082名兄弟姐妹，他们参加了儿童癌症幸存者研究，他们在1994年至2010年期间完成了一项评估一次或多次自杀念头的调查问题。自杀意念采用简要症状量表-18进行评估。死亡率数据由国家死亡指数确定。幸存者更有可能报告晚期(优势比(OR) =1.9；95%可信区间(CI) = 1.5-2.5)和复发性自杀意念（OR=2.6, 95% CI= 1.8-3.8）。身体健康状况不佳与幸存者自杀意念风险增加有关（晚期报告：OR=1.9, 95% CI= 1.3-2.7；复发：OR=1.9, 95% CI= 1.2-2.9）。自杀意念与全因死亡（HR= 1.3, 95% CI= 1.03-1.6）和外因死亡（HR=2.4, 95% CI= 1.4-4.1）的风险增加相关。儿童期癌症的成年幸存者有迟报和复发性自杀意念的风险，这与死亡风险增加有关。对成年幸存者的心理困扰进行常规筛查似乎是有必要的，特别是对患有慢性身体健康状况的幸存者。
Adult survivors of childhood cancer are at-risk for suicide ideation, though longitudinal patterns and rates of recurrent suicide ideation are unknown. We investigated the prevalence of late report (i.e. post-initial assessment) and recurrent suicide ideation in adult survivors of childhood cancer, identified predictors of suicide ideation, and examined associations among suicide ideation and mortality. Participants included 9,128 adult survivors of childhood cancer and 3,082 sibling controls enrolled in the Childhood Cancer Survivor Study who completed a survey question assessing suicide ideation on one or more occasions between 1994 and 2010. Suicide ideation was assessed using the Brief Symptom Inventory-18. Mortality data was ascertained from the National Death Index. Survivors were more likely to report late (Odds Ratio (OR) =1.9; 95% Confidence Interval (CI) =1.5–2.5) and recurrent suicide ideation (OR=2.6, 95% CI=1.8–3.8) compared to siblings. Poor physical health status was associated with increased risk of suicide ideation in survivors (late report: OR=1.9, 95% CI=1.3–2.7; recurrent: OR=1.9, 95% CI=1.2–2.9). Suicide ideation was associated with increased risk for all-cause mortality (Hazard Ratio (HR) =1.3, 95% CI=1.03–1.6) and death by external causes (HR=2.4, 95% CI=1.4–4.1). Adult survivors of childhood cancer are at-risk for late report and recurrent suicide ideation, which is associated with increased risk of mortality. Routine screening for psychological distress in adult survivors appears warranted, especially for survivors who develop chronic physical health conditions.
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影响因子：
45.3
作者：
Hem, E;Loge, JH;Ekeberg, O
通讯作者：
Ekeberg, O
影响因子：
45.3
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Recklitis, C;O'Leary, T;Diller, L
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Bowers, Daniel C.;Liu, Yan;Oeffinger, Kevin C.
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Smith GS
影响因子：
8
作者：
Stuber ML;Meeske KA;Krull KR;Leisenring W;Stratton K;Kazak AE;Huber M;Zebrack B;Uijtdehaage SH;Mertens AC;Robison LL;Zeltzer LK
通讯作者：
Zeltzer LK