The Role of Protein and Lipid Clustering in Lymphocyte Activation.
The Role of Protein and Lipid Clustering in Lymphocyte Activation.
复制标题
DOI：
10.3389/fimmu.2021.600961
复制
发表时间：
2021
影响因子：
7.3
通讯作者：
Owen DM
中科院分区：
文献类型：
--
作者：
Lamerton RE;Lightfoot A;Nieves DJ;Owen DM
淋巴细胞必须在响应潜在致病生物的信号而激活和避免来自人体自身细胞的刺激而激活之间取得微妙的平衡。对于细胞，如T细胞或B细胞，最大限度地提高效率和保真度，同时尽量减少串扰，复杂的信号通路是至关重要的。实现这种控制的一种方法是通过精心编排信号分子的时空组织，从而调节蛋白质-蛋白质相互作用的速率。在质膜上尤其如此，近端信号事件发生在质膜上，蛋白质微聚类现象已被广泛观察和表征。这篇综述将着重于蛋白质和脂质在细胞表面的不均匀分布，说明这种分布如何影响健康和疾病的信号传导。我们特别关注纳米级分子组织，最近通过显微镜技术和分析方法的进步，纳米级分子组织已经可以进行研究。
Lymphocytes must strike a delicate balance between activating in response to signals from potentially pathogenic organisms and avoiding activation from stimuli emanating from the body's own cells. For cells, such as T or B cells, maximizing the efficiency and fidelity, whilst minimizing the crosstalk, of complex signaling pathways is crucial. One way of achieving this control is by carefully orchestrating the spatiotemporal organization of signaling molecules, thereby regulating the rates of protein-protein interactions. This is particularly true at the plasma membrane where proximal signaling events take place and the phenomenon of protein microclustering has been extensively observed and characterized. This review will focus on what is known about the heterogeneous distribution of proteins and lipids at the cell surface, illustrating how such distributions can influence signaling in health and disease. We particularly focus on nanoscale molecular organization, which has recently become accessible for study through advances in microscope technology and analysis methodology.
登录
查看更多内容
影响因子：
3.4
作者：
DeMond, Andrew L.;Mossman, Kaspar D.;Groves, Jay T.
通讯作者：
Groves, Jay T.
影响因子：
4.4
作者：
Cheng, PC;Brown, BK;Pierce, SK
通讯作者：
Pierce, SK
影响因子：
16.6
作者：
Danylchuk, Dmytro, I;Moon, Seonah;Klymchenko, Andrey S.
通讯作者：
Klymchenko, Andrey S.
影响因子：
4.4
作者：
Krishnan, S;Nambiar, MP;Tsokos, GC
通讯作者：
Tsokos, GC
影响因子：
7.3
作者：
Fiala, Gina J.;Kaschek, Daniel;Schamel, Wolfgang W. A.
通讯作者：
Schamel, Wolfgang W. A.