Targeting ferroptosis as a vulnerability in cancer.
Targeting ferroptosis as a vulnerability in cancer.
复制标题
将铁下垂作为癌症的一个弱点。
DOI：
10.1038/s41568-022-00459-0
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发表时间：
2022-07
期刊：
影响因子：
--
通讯作者：
Gan B
中科院分区：
文献类型：
--
作者：
Lei G;Zhuang L;Gan B
铁下垂是一种铁依赖的调节性细胞死亡形式，由细胞膜上过氧化脂质的毒性积聚引发。近年来，铁下垂引起了癌症研究界的极大兴趣，部分原因是它是一种独特的细胞死亡方式，在机制和形态上不同于其他形式的细胞死亡，如细胞凋亡，因此，在癌症治疗方面具有巨大的潜力。在这篇综述中，我们总结了铁下垂诱导和防御机制的研究现状，剖析了铁下垂在肿瘤抑制和肿瘤免疫中的作用和机制，概念化了癌细胞对铁下垂的不同易感性，并探索了针对肿瘤中铁下垂的治疗策略。近年来，癌症中铁下垂领域的研究急剧上升，这在一定程度上是因为它有可能成为靶点。在这篇综述中，雷等人。提供铁下垂在肿瘤生长和进展中的作用和机制的最新综述，包括其在肿瘤免疫中的功能，强调它是一种可用于癌症治疗的脆弱性。
Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered enormous interest in cancer research communities, partly because it is a unique cell death modality that is mechanistically and morphologically different from other forms of cell death such as apoptosis and therefore, holds great potential for cancer therapy. In this Review, we summarize the current understanding of ferroptosis-inducing and ferroptosis defence mechanisms, dissect the roles and mechanisms of ferroptosis in tumour suppression and tumour immunity, conceptualize the diverse vulnerabilities of cancer cells to ferroptosis, and explore therapeutic strategies for targeting ferroptosis in cancer. In recent years, research in the field of ferroptosis in cancer has risen steeply and this is in part owing to its potential to be targeted. In this Review, Lei et al. provide an up-to-date synthesis of the roles and mechanisms of ferroptosis in tumour growth and progression including its function in tumour immunity, highlighting it as a vulnerability that can be exploited for cancer therapy.
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DOI：
10.1126/science.aaw9872
发表时间：
2020-04-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Badgley MA;Kremer DM;Maurer HC;DelGiorno KE;Lee HJ;Purohit V;Sagalovskiy IR;Ma A;Kapilian J;Firl CEM;Decker AR;Sastra SA;Palermo CF;Andrade LR;Sajjakulnukit P;Zhang L;Tolstyka ZP;Hirschhorn T;Lamb C;Liu T;Gu W;Seeley ES;Stone E;Georgiou G;Manor U;Iuga A;Wahl GM;Stockwell BR;Lyssiotis CA;Olive KP
通讯作者：
Olive KP
影响因子：
5.5
作者：
Chen X;Yu C;Kang R;Tang D
通讯作者：
Tang D
影响因子：
28.2
作者：
Carbone M;Harbour JW;Brugarolas J;Bononi A;Pagano I;Dey A;Krausz T;Pass HI;Yang H;Gaudino G
通讯作者：
Gaudino G
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
21.3
作者：
Friedmann Angeli JP;Schneider M;Proneth B;Tyurina YY;Tyurin VA;Hammond VJ;Herbach N;Aichler M;Walch A;Eggenhofer E;Basavarajappa D;Rådmark O;Kobayashi S;Seibt T;Beck H;Neff F;Esposito I;Wanke R;Förster H;Yefremova O;Heinrichmeyer M;Bornkamm GW;Geissler EK;Thomas SB;Stockwell BR;O'Donnell VB;Kagan VE;Schick JA;Conrad M
通讯作者：
Conrad M