Pharmacokinetics of Mycophenolic Acid after Intravenous Administration of Mycophenolate Mofetil to Healthy Cats.
Pharmacokinetics of Mycophenolic Acid after Intravenous Administration of Mycophenolate Mofetil to Healthy Cats.
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健康猫静脉注射霉酚酸酯后霉酚酸的药代动力学。
DOI：
10.1111/jvim.14827
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发表时间：
2017-11
影响因子：
2.6
通讯作者：
Villarino NF
中科院分区：
文献类型：
--
作者：
Slovak JE;Rivera SM;Hwang JK;Court MH;Villarino NF
Mycophenolate mofetil (MMF), the prodrug of mycophenolic acid (MPA), is becoming increasingly popular as an alternative immunosuppressant in feline medicine. Pharmacokinetic information is not available for cats. The purpose of this study was to determine whether MMF is biotransformed into the active metabolite MPA and to evaluate the disposition of MPA after a 2‐hour constant rate intravenous (IV) infusion of MMF in healthy cats. Healthy cats (n = 6). This was a prospective pilot study. All cats were administered MMF at 20 mg/kg every 12 hours over a 2‐hour constant rate infusion for 1 day. The concentrations of MPA and its derivatives in blood were determined using a validated UHPLC–UV method. All cats biotransformed MMF into MPA. The mean AUC0‐14 h ranged from 6 to 50 h*mg/L after IV dosing of MMF. Transient large bowel diarrhea was recorded in 2 of 6 cats after medication administration. The disposition of MPA in plasma was highly variable, which could result in high interindividual variability in the safety and efficacy of treatment with MMF in cats.
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影响因子：
3
作者：
Gudeman J;Jozwiakowski M;Chollet J;Randell M
通讯作者：
Randell M
影响因子：
1
作者：
Hori, Yasutomo;Takusagawa, Fumihiko;Higuchi, Sei-ichi
通讯作者：
Higuchi, Sei-ichi
影响因子：
1.2
作者：
Uechi, M;Matsuoka, M;Ishikawa, Y
通讯作者：
Ishikawa, Y
影响因子：
1.2
作者：
Peddle, Gordon D.;Singletary, Gretchen E.;Oyama, Mark A.
通讯作者：
Oyama, Mark A.
影响因子：
2.2
作者：
Caro-Vadillo, A.;Ynaraja-Ramirez, E.;Montoya-Alonso, J. A.
通讯作者：
Montoya-Alonso, J. A.