Regulation of Drosophila melanogaster pro-apoptotic gene hid.

Regulation of Drosophila melanogaster pro-apoptotic gene hid.
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DOI:
10.1007/s10495-009-0374-2
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发表时间:
2009-08
期刊:
影响因子:
7.2
通讯作者:
Su, Tin Tin
Su, Tin Tin
中科院分区:
生物学2区
文献类型:
--
作者:
Bilak, Amber;Su, Tin Tin
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一个人一生中所做的关键决定包括是否生育以及多久生育一次,在群体中扮演什么角色,以及在某些条件下是生是死。类似的决定也发生在细胞层面上:是否分裂,在多细胞后生动物发育的背景下承担什么样的命运,以及在某些条件下,是生是死。促凋亡基因hid在果蝇细胞死亡过程中起重要作用。在这里,我们回顾了根据细胞的生死选择而存在的各种水平的控制来调节Hid。
Key decisions one makes in a lifetime include whether and how often to reproduce, what role to play in the community and, under certain conditions, whether to live or die. Similar decisions are also made at the level of cells: whether to divide, what fate to assume in the multicellular context of metazoan development and, under certain conditions, whether to live or to die. The pro-apoptotic gene hid plays an important role in the execution of cell death in Drosophila. Here, we review the various levels of control that exist to regulate Hid according to the life-or-death choice of a cell.
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