Targeting the bacteria-host interface: strategies in anti-adhesion therapy.
Targeting the bacteria-host interface: strategies in anti-adhesion therapy.
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DOI：
10.4161/viru.24606
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发表时间：
2013-05-15
期刊：
影响因子：
5.2
通讯作者：
Orth K
中科院分区：
文献类型：
--
作者：
Krachler AM;Orth K
细菌感染是世界范围内发病率和死亡率的主要原因，由于抗生素耐药菌株的增加，治疗变得越来越困难。开发能够抵御不断增加的细菌耐药机制的新抗菌素变得越来越具有挑战性。这就需要开发预防和治疗细菌感染的替代方法。细菌感染的第一步是病原体与宿主细胞的粘附。病原体的定植和侵入宿主组织的能力严格依赖于这一过程。因此，干扰粘连（抗粘连治疗）是预防或治疗细菌感染的有效方法。本文简要介绍了细菌附着于宿主细胞的一般概念，以此为基础提出了不同的干扰病原体粘附的策略。我们进一步讨论了抗黏附治疗的优点和缺点以及需要改进的问题，以便使抗黏附化合物成为传统抗菌剂的更广泛应用的替代品。
Bacterial infections are a major cause of morbidity and mortality worldwide and are increasingly problematic to treat due to the rise in antibiotic-resistant strains. It becomes more and more challenging to develop new antimicrobials that are able to withstand the ever-increasing repertoire of bacterial resistance mechanisms. This necessitates the development of alternative approaches to prevent and treat bacterial infections. One of the first steps during bacterial infection is adhesion of the pathogen to host cells. A pathogen’s ability to colonize and invade host tissues strictly depends on this process. Thus, interference with adhesion (anti-adhesion therapy) is an efficient way to prevent or treat bacterial infections. As a basis to present different strategies to interfere with pathogen adhesion, this review briefly introduces general concepts of bacterial attachment to host cells. We further discuss advantages and disadvantages of anti-adhesion treatments and issues that are in need of improvement so as to make anti-adhesion compounds a more broadly applicable alternative to conventional antimicrobials.
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影响因子：
5.7
作者：
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影响因子：
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