Nonsteroidal anti-inflammatory drugs for the prevention of colon cancer.

Nonsteroidal anti-inflammatory drugs for the prevention of colon cancer.
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用于预防结肠癌的非甾体类抗炎药。

DOI:
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发表时间:
1993
期刊:
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
影响因子:
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通讯作者:
H. Berkel
H. Berkel
中科院分区:
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文献类型:
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作者:
Donna Thrner;H. Berkel

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目的 总结非甾体抗炎药(NSAID)对结肠肿瘤生长影响的动物和人体研究结果,并概述可能的机制。 数据源 1992年6月以前发表的英文研究论文均来自MEDLINE。 资料选择 对9篇关于息肉癌序列的文章进行了综述,8篇关于NSAID抑制肿瘤的明显病理生理学方面,22篇关于NSAID对结肠癌发生作用的动物和人体研究。 结果 动物和人体研究结果表明,非甾体抗炎药的抗癌作用,这些药物是有效的,在防止肿瘤生长的结肠。 结论 在人类中的干预研究是必要的,以阐明非甾体抗炎药的治疗可能性,特别是在人群中的结肠癌的发展风险增加。
OBJECTIVE To summarize the results of animal and human studies of the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on neoplastic growth in the colon and to outline the possible mechanisms involved. DATA SOURCES Research articles published in English before June 1992 were identified from MEDLINE. STUDY SELECTION Nine articles on the polyp-cancer sequence were reviewed, 8 on the apparent pathophysiologic aspects of tumour inhibition by NSAIDs and 22 on animal and human research into the effect of NSAIDs on colon carcinogenesis. RESULTS The results of animal and human research into the anticarcinogenic effect of NSAIDs suggest that the drugs are effective in preventing tumour growth in the colon. CONCLUSIONS Intervention studies in humans are necessary to elucidate the therapeutic possibilities of NSAIDs, particularly in populations at increased risk for the development of colon cancer.
DOI: --
发表时间: 1991
期刊: Cancer research
影响因子: 11.2
作者:
Chinthalapally;V. Rao;K. Tokumo;J. Rigotty;E. Zang;G. Kelloff;Bandaru S. Reddy
通讯作者: Chinthalapally;V. Rao;K. Tokumo;J. Rigotty;E. Zang;G. Kelloff;Bandaru S. Reddy
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DOI: --
发表时间: 1987
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影响因子: 11.2
作者:
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DOI: --
发表时间: 1992
期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子: --
作者:
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DOI: 10.1136/bmj.299.6710.1247
发表时间: 1989-11-18
影响因子: 105.7
作者:
PAGANINIHILL, A;CHAO, A;HENDERSON, BE
通讯作者: HENDERSON, BE
DOI: 10.1093/jnci/83.5.355
发表时间: 1991-03-06
期刊: JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子: --
作者:
ROSENBERG, L;PALMER, JR;SHAPIRO, S
通讯作者: SHAPIRO, S