Stable pediatric kidney transplant recipients run higher urine indoleamine 2, 3 dioxygenase (IDO) levels than healthy children.
Stable pediatric kidney transplant recipients run higher urine indoleamine 2, 3 dioxygenase (IDO) levels than healthy children.
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DOI：
10.1111/petr.12232
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发表时间：
2014-05
影响因子：
1.3
通讯作者：
Dharnidharka VR
中科院分区：
文献类型：
--
作者：
Al Khasawneh E;Gupta S;Tuli SY;Shahlaee AH;Garrett TJ;Schechtman KB;Dharnidharka VR
Immune cells utilize the indoleamine 2,3 dioxygenase (IDO) enzymatic conversion of tryptophan (trp) to kynurenines (kyn) to determine T cell activation versus anergy/apoptosis. In prior studies, urine IDO levels were higher in rejecting renal allografts than in stable state. However, urine IDO levels in healthy subjects or children are unknown. As a corollary to a larger longitudinal and prospective study of serum and urine IDO levels for transplant immune monitoring, here we analyzed the difference between urine IDO levels in stable post-transplant versus healthy children. IDO levels were measured by tandem mass spectrometry and expressed as kyn/trp ratios. We compared one-time urine samples, from 34 well children at general pediatric clinics, to the first month post-transplant urine samples from 18 children, while in stable state (no acute rejection or major infection event in next 30 days). Urine kyn/trp ratios were significantly higher in stable children in first month post-kidney transplant (median 16.6, range 3.9-44.0) versus healthy children (median 9.2, range 3.51-17.0; p value = 0.0057 by non-parametric Mann-Whitney test). Higher urine IDO levels even with stable transplant suggests a continuous ongoing low-grade allorecognition/inflammatory process. Our data also provide baseline urine IDO levels in healthy subjects for use in future studies. (word count = 200)
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影响因子：
1.3
作者：
Dharnidharka VR;Gupta S;Al Khasawneh E;Haafiz A;Shuster JJ;Theriaque DW;Shahlaee AH;Garrett TJ
通讯作者：
Garrett TJ
DOI：
10.1097/ppo.0b013e3181eb3343
发表时间：
2010-07
期刊：
Cancer journal (Sudbury, Mass.)
影响因子：
--
作者：
Soliman H;Mediavilla-Varela M;Antonia S
通讯作者：
Antonia S
影响因子：
19.6
作者：
Brandacher, G.;Cakar, F.;Fuchs, D.
通讯作者：
Fuchs, D.
DOI：
10.1016/j.biocel.2007.01.004
发表时间：
2007-01-01
影响因子：
4
作者：
King, Nicholas J. C.;Thomas, Shane R.
通讯作者：
Thomas, Shane R.
影响因子：
6.2
作者：
Dharnidharka VR;Al Khasawneh E;Gupta S;Shuster JJ;Theriaque DW;Shahlaee AH;Garrett TJ
通讯作者：
Garrett TJ