Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders.
Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders.
复制标题
DOI：
10.7150/ijbs.23247
复制
发表时间：
2018
影响因子：
9.2
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Hussain G;Rasul A;Anwar H;Aziz N;Razzaq A;Wei W;Ali M;Li J;Li X
神经退行性疾病通常被定义为神经元选择性丧失的疾病。传统的和新型的分子都已经过测试，但它们仅提供症状优势以及丰富的副作用。能够阻止这些疾病的病理学的更引人注目的分子的发现将被视为当今时代的奇迹。有几种合成化合物可供使用，但它们可能会导致其他一些健康问题。因此，来自植物和其他来源的天然分子正在被发现来替代现有的药物。在传统的药物治疗中，据报道有几种植物具有治疗作用。来自药用植物的植物化学物质可以为合成分子提供更好、更安全的替代品。已发现许多植物化学物质可以治愈人体的多种疾病。本文综述了植物生物碱的潜在功效，这些生物碱对多种 NDD 具有潜在的治疗作用，包括阿尔茨海默病 (AD)、亨廷顿病 (HD)、帕金森病 (PD)、癫痫、精神分裂症和中风。生物碱包括异喹啉、吲哚、吡咯并吲哚、羟吲哚、哌啶、吡啶、阿朴啡、长春花、β-咔啉、甲基呫吨、石松和赤藓碱副产物。生物碱通过作为毒蕈碱和腺苷受体激动剂、抗氧化剂、抗淀粉样蛋白和 MAO 抑制剂、乙酰胆碱酯酶和丁酰胆碱酯酶抑制剂、α-突触核蛋白聚集抑制剂、多巴胺能和尼古丁激动剂以及 NMDA 拮抗剂，在改善这些疾病的病理生理学方面发挥积极作用。
Neurodegenerative diseases are conventionally demarcated as disorders with selective loss of neurons. Conventional as well as newer molecules have been tested but they offer just symptomatic advantages along with abundant side effects. The discovery of more compelling molecules that can halt the pathology of these diseases will be considered as a miracle of present time. Several synthetic compounds are available but they may cause several other health issues. Therefore, natural molecules from the plants and other sources are being discovered to replace available medicines. In conventional medicational therapies, several plants have been reported to bestow remedial effects. Phytochemicals from medicinal plants can provide a better and safer alternative to synthetic molecules. Many phytochemicals have been identified that cure the human body from a number of diseases. The present article reviews the potential efficacy of plant-derived alkaloids, which possess potential therapeutic effects against several NDDs including Alzheimer's disease (AD), Huntington disease (HD), Parkinson's disease (PD), Epilepsy, Schizophrenia, and stroke. Alkaloids include isoquinoline, indole, pyrroloindole, oxindole, piperidine, pyridine, aporphine, vinca, β-carboline, methylxanthene, lycopodium, and erythrine byproducts. Alkaloids constitute positive roles in ameliorating pathophysiology of these illnesses by functioning as muscarinic and adenosine receptors agonists, anti-oxidant, anti-amyloid and MAO inhibitors, acetylcholinestrase and butyrylcholinesterase inhibitor, inhibitor of α-synuclein aggregation, dopaminergic and nicotine agonist, and NMDA antagonist.
登录
查看更多内容
影响因子：
3.1
作者：
Akaike, Akinori;Takada-Takatori, Yuki;Izumi, Yasuhiko
通讯作者：
Izumi, Yasuhiko
影响因子：
1.7
作者：
Amirkia, Vafa;Heinrich, Michael
通讯作者：
Heinrich, Michael
对Berberis ulgaris及其活性成分的体外生物学评估：抗氧化剂，抗乙酰胆碱酯酶，抗糖尿病和抗癌作用。
影响因子：
--
作者：
Abd El-Wahab AE;Ghareeb DA;Sarhan EE;Abu-Serie MM;El Demellawy MA
通讯作者：
El Demellawy MA
影响因子：
2.7
作者：
Al-Baghdadi, Osamah B.;Prater, Natalie I.;Geldenhuys, Werner J.
通讯作者：
Geldenhuys, Werner J.
DOI：
10.1590/1414-431x20143697
发表时间：
2014-04-01
影响因子：
2.3
作者：
Almeida, M.B.;Costa-Malaquias, A.;Crespo-López, M.E.
通讯作者：
Crespo-López, M.E.