The effects of tryptophan depletion on neural responses to emotional words in remitted depression.
The effects of tryptophan depletion on neural responses to emotional words in remitted depression.
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DOI：
10.1016/j.biopsych.2009.05.002
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发表时间：
2009-09-01
影响因子：
10.6
通讯作者：
Drevets, Wayne C.
中科院分区：
文献类型：
--
作者：
Roiser, Jonathan P.;Levy, Jamey;Fromm, Stephen J.;Nugent, Allison C.;Talagala, S. Lalith;Hasler, Gregor;Henn, Fritz A.;Sahakian, Barbara J.;Drevets, Wayne C.
关键词：
Major depressive disorder (MDD) has been associated with both dysfunction of the central serotonergic system and abnormal responses to emotional stimuli. We used acute tryptophan depletion (ATD) to investigate the effect of temporarily reducing brain serotonin synthesis on neural and behavioural responses to emotional stimuli in remitted MDD subjects (rMDD) and healthy controls. Twenty controls and 23 rMDD subjects who had been unmedicated and in remission for ≥3 months completed the study. Following tryptophan or sham depletion, participants performed an emotional-processing task during functional magnetic resonance imaging. In addition, resting-state regional blood-flow was measured using arterial spin labelling. Neither group exhibited significant mood-change following ATD. However, tryptophan depletion differentially affected the groups in terms of hemodynamic responses to emotional words in a number of structures implicated in the pathophysiology of MDD, including medial thalamus and caudate. These interactions were driven by increased responses to emotional words in the controls, with little effect in the patients under the ATD condition. Following ATD, habenula blood-flow increased significantly in the rMDD subjects relative to the controls, and increasing amygdala blood-flow was associated with more negative emotional bias score across both groups. These data provide evidence for elevated habenula blood-flow and alterations in the neural processing of emotional stimuli following ATD in rMDD subjects, even in the absence of overt mood-change. However, further studies are required to determine whether these findings represent mechanisms of resilience or vulnerability to MDD.
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影响因子：
10.6
作者：
Drevets, WC
通讯作者：
Drevets, WC
DOI：
10.1017/s1461145707008140
发表时间：
2008-06-01
影响因子：
4.8
作者：
Hirvonen, Jussi;Karlsson, Hasse;Hietala, Jarmo
通讯作者：
Hietala, Jarmo
影响因子：
4.7
作者：
Harmer, Catherine J.
通讯作者：
Harmer, Catherine J.
影响因子：
3.1
作者：
Cowen, PJ
通讯作者：
Cowen, PJ
影响因子：
10.6
作者：
Hayward, G;Goodwin, GM;Harmer, CJ
通讯作者：
Harmer, CJ