Bodyweight assessment of enamelin null mice.
Bodyweight assessment of enamelin null mice.
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DOI：
10.1155/2013/246861
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发表时间：
2013
影响因子：
--
通讯作者：
Hu JC
中科院分区：
文献类型：
--
作者：
Chan AH;Lertlam R;Simmer JP;Wang CN;Hu JC
Enam无效小鼠似乎比野生型小鼠小，这促使了釉质缺陷对营养摄入和体重增加（BWG）产生负面影响的假设。我们比较了Enam−/−和野生型小鼠从出生（D 0）到第42天（D42）的BWG。野生型（WT）和Enam−/−（N）小鼠给予硬饲料（HC）或软饲料（SC）。研究了四个实验组：WTHC，WTSC，NHC和NSC。从D 0至D21获得母体体重（DBW）和平均窝仔体重（ALBW）。D21后，将幼仔与母亲分开，并提供相同类型的食物。测量窝仔体重直至D42。采用单因素方差分析，以7天为间隔比较ALBW，而DBW对ALBW的影响采用混合模型分析。在D21时，维持硬食物（NHC）的Enam−/−小鼠的ALBW显著低于两个WT组，并且差异持续到成年早期。维持软饲料（NSC）的Enam−/−小鼠的ALBW呈降低趋势，但与WT组相比无显著差异。我们得出结论，基因型，影响釉质完整性，食物硬度影响出生后和年轻的成年小鼠体重增加。
The Enam null mice appear to be smaller than wild-type mice, which prompted the hypothesis that enamel defects negatively influence nutritional intake and bodyweight gain (BWG). We compared the BWG of Enam−/− and wild-type mice from birth (D0) to Day 42 (D42). Wild-type (WT) and Enam−/− (N) mice were given either hard chow (HC) or soft chow (SC). Four experimental groups were studied: WTHC, WTSC, NHC, and NSC. The mother's bodyweight (DBW) and the average litter bodyweight (ALBW) were obtained from D0 to D21. After D21, the pups were separated from the mother and provided the same type of food. Litter bodyweights were measured until D42. ALBW was compared at 7-day intervals using one-way ANOVA, while the influence of DBW on ALBW was analyzed by mixed-model analyses. The ALBW of Enam−/− mice maintained on hard chow (NHC) was significantly lower than the two WT groups at D21 and the differences persisted into young adulthood. The ALBW of Enam−/− mice maintained on soft chow (NSC) trended lower, but was not significantly different than that of the WT groups. We conclude that genotype, which affects enamel integrity, and food hardness influence bodyweight gain in postnatal and young adult mice.
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DOI：
10.1073/pnas.0638023100
发表时间：
2003-04-01
影响因子：
11.1
作者：
Kawasaki, K;Weiss, KM
通讯作者：
Weiss, KM
影响因子：
3.5
作者：
Masuya, H;Shimizu, K;Shiroishi, T
通讯作者：
Shiroishi, T
影响因子：
7.6
作者：
Kim, JW;Simmer, JP;Hu, JCC
通讯作者：
Hu, JCC
影响因子：
10.7
作者：
Al-Hashimi, Nawfal;Lafont, Anne-Gaelle;Sire, Jean-Yves
通讯作者：
Sire, Jean-Yves
影响因子：
7.6
作者：
Chan HC;Mai L;Oikonomopoulou A;Chan HL;Richardson AS;Wang SK;Simmer JP;Hu JC
通讯作者：
Hu JC