Fibrillar peptide gels in biotechnology and biomedicine.
Fibrillar peptide gels in biotechnology and biomedicine.
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DOI：
10.1002/bip.21326
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发表时间：
2010
期刊：
影响因子：
2.9
通讯作者：
Collier, Joel H.
中科院分区：
文献类型：
--
作者：
Jung, Jangwook P.;Gasiorowski, Joshua Z.;Collier, Joel H.
Peptides, peptidomimetics, and peptide derivatives that self-assemble into fibrillar gels have received increasing interest as synthetic extracellular matrices for applications in 3D cell culture and regenerative medicine. Recently, several of these fibrillizing molecules have been functionalized with bioactive components such as cell-binding ligands, degradable sequences, drug-eluting compounds, and chemical modifications for cross-linking, producing gels that can reliably display multiple factors simultaneously. This capacity for incorporating precise levels of many different biological and chemical factors is advantageous given the natural complexity of cell-matrix interactions that many current biomaterial strategies seek to mimic. In this review, recent efforts in the area of fibril-forming peptide materials are described, and advantages of biomaterials containing multiple modular elements are outlined. In addition, a few hurdles and open questions surrounding fibrillar peptide gels are discussed, including issues of the materials’ structural heterogeneity, challenges in fully characterizing the diversity of their self-assembled structures, and incomplete knowledge of how the materials are processed in vivo.
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