The spatial and temporal structure of neural activity across the fly brain.
The spatial and temporal structure of neural activity across the fly brain.
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DOI：
10.1038/s41467-023-41261-2
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发表时间：
2023-09-11
影响因子：
16.6
通讯作者：
Axel R
中科院分区：
文献类型：
--
作者：
Schaffer ES;Mishra N;Whiteway MR;Li W;Vancura MB;Freedman J;Patel KB;Voleti V;Paninski L;Hillman EMC;Abbott LF;Axel R
全脑神经元活动的空间和时间尺度是什么？我们使用扫描共聚焦平面激发（SCAPE）显微镜对成年果蝇大容量大脑中的所有细胞进行了高时空分辨率成像，同时果蝇从事各种自发行为。这揭示了行为在多个空间和时间尺度上的神经表征。大多数神经元的活动与奔跑和击打相关（或反相关）的时间尺度从几秒到一分钟不等。梳洗引起的全球反应较弱。与行为不直接相关的显著剩余活动是高维的，反映了空间组织的小簇神经元的活动，这些神经元可能对应于遗传定义的细胞类型。这些集群参与全局动态，表明神经活动反映了局部和广泛分布成分的组合。这表明，具有高度特定功能的微电路被提供了它们运行的更大背景的知识。苍蝇大脑中的神经区被运动激活。在这里，作者表明，这种与运动相关的活动涉及到背蝇大脑中的大多数神经元，包括已知的基因定义的神经元，看似不相关的功能。
What are the spatial and temporal scales of brainwide neuronal activity? We used swept, confocally-aligned planar excitation (SCAPE) microscopy to image all cells in a large volume of the brain of adult Drosophila with high spatiotemporal resolution while flies engaged in a variety of spontaneous behaviors. This revealed neural representations of behavior on multiple spatial and temporal scales. The activity of most neurons correlated (or anticorrelated) with running and flailing over timescales that ranged from seconds to a minute. Grooming elicited a weaker global response. Significant residual activity not directly correlated with behavior was high dimensional and reflected the activity of small clusters of spatially organized neurons that may correspond to genetically defined cell types. These clusters participate in the global dynamics, indicating that neural activity reflects a combination of local and broadly distributed components. This suggests that microcircuits with highly specified functions are provided with knowledge of the larger context in which they operate. Neuropil regions across the fly brain are activated by locomotion. Here, authors show that this movement-related activity involves most neurons in the dorsal fly brain, including genetically defined neurons with known, seemingly unrelated functions.
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