Human Innate Lymphoid Cells in Influenza Infection and Vaccination.
Human Innate Lymphoid Cells in Influenza Infection and Vaccination.
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DOI：
10.1615/critrevimmunol.2021040801
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发表时间：
2021
影响因子：
1.3
通讯作者：
Sambhara, Suryaprakash
中科院分区：
文献类型：
--
作者：
Kumar, Amrita;Kumari, Rashmi;Liu, Timothy;Cao, Weiping;Davidson, Bruce A.;Knight, Paul R.;Sambhara, Suryaprakash
流感是一种高度传染性的呼吸道病毒，可导致轻度至重度呼吸道疾病以及死亡，仍然是对人类健康的严重威胁。每年接种疫苗是控制流感的最具成本效益的方法;然而，疫苗不能提供对具有流行和大流行潜力的新菌株的保护。已经开发了几种抗病毒药物来治疗流感，但抗病毒耐药株迅速出现。因此，迫切需要了解病毒及其与宿主免疫系统的相互作用，以便开发新的预防和治疗干预策略。先天性淋巴样细胞（inate lymphoid cells，ILC）是存在于外周循环和粘膜组织中的免疫细胞家族，在调节组织稳态、炎症和免疫中起重要作用。本文综述了目前对ILC在人类流感病毒感染中的认识和治疗潜力。
Influenza is a highly contagious respiratory virus that causes mild to severe respiratory illness, as well as death, and remains a serious threat to human health. Annual vaccination is the most cost-effective way to control influenza; however, the vaccine does not provide protection against emerging strains with epidemic and pandemic potential. Several antivirals have been developed to treat influenza but there is a rapid emergence of antiviral resistant strains. Therefore, there is an urgent need to understand the virus and its interactions with the host immune system so that novel strategies can be developed for prophylactic and therapeutic interventions. Innate lymphoid cells (ILCs), a family of immune cells present in the peripheral circulation and in mucosal tissues, play an important role in regulation of tissue homeostasis, inflammation, and immunity. This review examines the current understanding and therapeutic potential of ILCs during influenza virus infection in humans.
影响因子：
4.6
作者：
Rose DL;Reagin KL;Oliva KE;Tompkins SM;Klonowski KD
通讯作者：
Klonowski KD
影响因子：
--
作者：
Mathew A
通讯作者：
Mathew A
DOI：
10.1084/jem.156.4.1222
发表时间：
1982-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Djeu JY;Stocks N;Zoon K;Stanton GJ;Timonen T;Herberman RB
通讯作者：
Herberman RB