Regulation and Function of NK and T Cells During Dengue Virus Infection and Vaccination.

Regulation and Function of NK and T Cells During Dengue Virus Infection and Vaccination.
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DOI:
10.1007/978-981-10-8727-1_18
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发表时间:
2018
影响因子:
--
通讯作者:
Mathew A
Mathew A
中科院分区:
医学4区
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作者:
Mathew A

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这篇综述的重点是讨论在过去10年中的研究结果,这些研究结果促进了我们对人类NK细胞对登革病毒反应的理解。我们将回顾最近发现的NK细胞上的激活和抑制受体与登革病毒的相互作用,人类NK细胞对自然登革感染的反应,并强调NK细胞可能形成适应性免疫反应的可能相互作用。T细胞对自然登革热感染的反应将由Laura Rivino在第二章中进行综述。10.1007/978-981-10-8727-1_17。随着大量登革热疫苗临床试验的出现,我们还将回顾T和NK细胞对登革热病毒疫苗接种的免疫应答。随着我们对NK细胞多种功能的理解不断深入,越来越清楚的是,人类NK细胞对病毒感染的反应比最初认识的要复杂得多。
The focus of this review is to discuss findings in the last 10 years that have advanced our understanding of human NK cell responses to dengue virus. We will review recently identified interactions of activating and inhibitory receptors on NK cells with dengue virus, human NK responses to natural dengue infection and highlight possible interactions by which NK cells may shape adaptive immune responses. T cell responses to natural dengue infection will be reviewed by Laura Rivino in Chap. 10.1007/978-981-10-8727-1_17. With the advent of numerous dengue vaccine clinical trials, we will also review T and NK cell immune responses to dengue virus vaccination. As our understanding of the diverse functions of NK cell has advanced, it has become increasingly clear that human NK cell responses to viral infections are more complicated than initially recognized.
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