Outcome domains reported in calcium pyrophosphate deposition studies: A scoping review by the OMERACT CPPD working group.
Outcome domains reported in calcium pyrophosphate deposition studies: A scoping review by the OMERACT CPPD working group.
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DOI：
10.1016/j.semarthrit.2020.05.015
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发表时间：
2020-08
影响因子：
5
通讯作者：
Dalbeth N
中科院分区：
文献类型：
--
作者：
Cai K;Fuller A;Hensey O;Grossberg D;Christensen R;Shea B;Singh JA;Abhishek A;Tedeschi S;Dalbeth N
虽然焦磷酸钙沉积（CPPD）是常见的，但CPPD研究没有经过验证的结果域和/或测量。这项工作的目的是确定在CPPD先前临床研究中报告的领域，为CPPD研究核心领域的开发提供信息。我们对CPPD中的临床研究进行了范围文献综述，检索了Medline（通过PubMed）、EMBASE和科克伦对照试验中心注册中心（CENTRAL）数据库;发表时间为1946年1月1日至2020年1月7日。提取所有报告的结局和研究设计数据，并映射到OMERACT Filter 2.1定义的核心领域和领域。方案在PROSPERO上注册（CRD：42019137075; 09-07-2019）。共识别出112篇论文，包括109项观察性研究和3项随机对照试验。大多数研究报告了OA伴CPPD或急性CPP结晶性关节炎的临床表现。确定了映射到22个领域的结局;最常报告的指标映射到以下领域/子领域：成像（成像测试中的关节损伤- 59项研究;影像学检查显示关节钙化- 28项研究），关节疼痛（26项研究），治疗反应（23项研究），治疗副作用（15项研究），关节液或血液中的炎症（ESR或C反应蛋白- 12项研究;滑液标志物- 4项研究;其他血液标志物- 2项研究），整体功能（14项研究），关节肿胀（12项研究）和关节活动范围（10项研究）。很少有研究涉及与生活影响、社会/资源使用或寿命有关的领域。CPPD研究中报告的结局存在很大差异。最常报告的结局与影像学表现、关节疼痛和对治疗领域的反应有关。
Although calcium pyrophosphate deposition (CPPD) is common, there are no validated outcome domains and/or measurements for CPPD studies. The aim of this work was to identify domains that have been reported in prior clinical studies in CPPD, to inform the development of a core set of domains for CPPD studies. We performed a scoping literature review for clinical studies in CPPD, searching in Medline (via PubMed), EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) databases; published from January 1, 1946 to January 7, 2020. All reported outcomes and study design data were extracted and mapped to the core areas and domains as defined by the OMERACT Filter 2.1.The protocol was registered on PROSPERO (CRD: 42019137075; 09-07-2019). There were 112 papers identified, comprising of 109 observational studies and three randomized controlled trials. Most studies reported clinical presentations of OA with CPPD or acute CPP crystal arthritis. Outcomes that mapped to 22 domains were identified; the most frequently reported measures mapped to the following domains/sub-domains: imaging (joint damage on imaging tests - 59 studies; joint calcification on imaging tests - 28 studies), joint pain (26 studies), response to treatment (23 studies), side effects of treatment (15 studies), inflammation in the joint fluid or blood (ESR or C-reactive protein - 12 studies; synovial fluid markers - 4 studies; other blood markers - 2 studies), overall function (14 studies), joint swelling (12 studies) and range of joint movement (10 studies). Very few studies mapped to domains related to life impact, societal/resource use or longevity. There is substantial variability in outcomes reported in CPPD studies. Outcomes that map to imaging manifestations, joint pain and response to treatment domains are most often reported.
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