Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population
Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population
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中国人群循环miR-132与非酒精性脂肪肝的关系
DOI：
10.1186/s41065-020-00136-y
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发表时间：
2020-05
期刊：
影响因子：
2.7
通讯作者：
Jia Weiping
中科院分区：
文献类型：
--
作者：
Zong Yicen;Yan Jing;Jin Li;Xu Bo;He Zhen;Zhang Rong;Hu Cheng;Jia Weiping
背景非侵入性诊断标志物对非酒精性脂肪性肝病（NAFLD）的早期筛查具有重要意义。MicroRNAs （miRNAs）在包括NAFLD在内的许多代谢性疾病中发挥着重要作用。因此，本研究以中国人群为研究对象，探讨循环miR-132与NAFLD之间可能的相关性。结果调整年龄、性别、体重指数（BMI）后，经logistic回归分析，非2型糖尿病（T2DM）组血清miR-132与NAFLD呈正相关（OR = 3.082 [1.057, 8.988]，P= 0.039）。此外,在non-T2DM子群,在调整年龄、性别、体重指数、血清mir - 132与ALT显著相关(β±SE = 0.005±0.002,P = 0.018), TG(β±SE = 0.072±0.029,P = 0.015),台塑(β±SE = 0.123±0.058,P = 0.036),γgt(β±SE = 0.002±0.001,P = 0.047),载脂蛋白e(β±SE = 0.038±0.002,P = 0.017)。结论在一项中国横断面研究中发现血清miR-132与NAFLD风险相关。这一发现为NAFLD的早期筛查和诊断提供了前瞻性的研究方向。
BackgroundNon-invasive diagnostic markers are of great importance for early screening nonalcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) play significant roles in many metabolic disease, including NAFLD. Therefore, this study focusd on a Chinese population to explore the possible correlation between circulating miR-132 and NAFLD.ResultsSerum miR-132 was positively associated with NAFLD in non-type 2 diabetes mellitus (T2DM) groups by logistic regression (OR = 3.082 [1.057, 8.988],P= 0.039) after adjusting age, sex, and body mass index (BMI). Additionally, in non-T2DM subgroup, after adjusting age, sex, bmi, serum miR-132 was significantly associated with ALT (β ± SE = 0.005 ± 0.002,P= 0.018), TG (β ± SE = 0.072 ± 0.029,P= 0.015), FPG (β ± SE = 0.123 ± 0.058,P= 0.036), γ-GT (β ± SE = 0.002 ± 0.001,P= 0.047), apoE (β ± SE = 0.038 ± 0.002,P= 0.017) .ConclusionsSerum miR-132 was found to be associated with NAFLD risk in a Chinese cross-section study. This finding provides a prospective research direction for early screening and diagnosing NAFLD.
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影响因子：
5.3
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影响因子：
14.6
作者：
L. Adams;P. Angulo;K. Lindor
通讯作者：
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DOI：
10.1016/j.bpg.2010.08.005
发表时间：
2010-10-01
影响因子：
3.2
作者：
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DOI：
10.1007/978-3-319-11251-0_36
发表时间：
2016
期刊：
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通讯作者：
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影响因子：
32.4
作者：
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通讯作者：
Soreq, Hermona