Mitochondrial Structure and Polarity in Dendrites and the Axon Initial Segment Are Regulated by Homeostatic Plasticity and Dysregulated in Fragile X Syndrome.
Mitochondrial Structure and Polarity in Dendrites and the Axon Initial Segment Are Regulated by Homeostatic Plasticity and Dysregulated in Fragile X Syndrome.
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树突和轴突起始段的线粒体结构和极性受稳态可塑性调节，脆性X综合征中的调节异常
DOI：
10.3389/fcell.2021.702020
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发表时间：
2021
影响因子：
5.5
通讯作者：
Bassell GJ
中科院分区：
文献类型：
--
作者：
Bülow P;Wenner PA;Faundez V;Bassell GJ
Mitochondrial dysfunction has long been overlooked in neurodevelopmental disorders, but recent studies have provided new links to genetic forms of autism, including Rett syndrome and fragile X syndrome (FXS). Mitochondria show plasticity in morphology and function in response to neuronal activity, and previous research has reported impairments in mitochondrial morphology and function in disease. We and others have previously reported abnormalities in distinct types of homeostatic plasticity in FXS. It remains unknown if or how activity deprivation triggering homeostatic plasticity affects mitochondria in axons and/or dendrites and whether impairments occur in neurodevelopmental disorders. Here, we test the hypothesis that mitochondria are structurally and functionally modified in a compartment-specific manner during homeostatic plasticity using a model of activity deprivation in cortical neurons from wild-type mice and that this plasticity-induced regulation is altered in Fmr1-knockout (KO) neurons. We uncovered dendrite-specific regulation of the mitochondrial surface area, whereas axon initial segment (AIS) mitochondria show changes in polarity; both responses are lost in the Fmr1 KO. Taken together, our results demonstrate impairments in mitochondrial plasticity in FXS, which has not previously been reported. These results suggest that mitochondrial dysregulation in FXS could contribute to abnormal neuronal plasticity, with broader implications to other neurodevelopmental disorders and therapeutic strategies.
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DOI：
10.1523/jneurosci.4650-11.2012
发表时间：
2012-04-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Niere F;Wilkerson JR;Huber KM
通讯作者：
Huber KM
DOI：
10.1038/nrn4001
发表时间：
2015-10
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Richter JD;Bassell GJ;Klann E
通讯作者：
Klann E
影响因子：
3.6
作者：
Bülow P;Zlatic SA;Wenner PA;Bassell GJ;Faundez V
通讯作者：
Faundez V
影响因子：
25
作者：
Shen, Minjie;Wang, Feifei;Zhao, Xinyu
通讯作者：
Zhao, Xinyu
DOI：
10.1523/jneurosci.3660-10.2010
发表时间：
2010-12-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Soden ME;Chen L
通讯作者：
Chen L