FMRP attenuates activity dependent modifications in the mitochondrial proteome.
FMRP attenuates activity dependent modifications in the mitochondrial proteome.
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DOI：
10.1186/s13041-021-00783-w
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发表时间：
2021-04-30
期刊：
影响因子：
3.6
通讯作者：
Faundez V
中科院分区：
文献类型：
--
作者：
Bülow P;Zlatic SA;Wenner PA;Bassell GJ;Faundez V
Homeostatic plasticity is necessary for the construction and maintenance of functional neuronal networks, but principal molecular mechanisms required for or modified by homeostatic plasticity are not well understood. We recently reported that homeostatic plasticity induced by activity deprivation is dysregulated in cortical neurons from Fragile X Mental Retardation protein (FMRP) knockout mice (Bulow et al. in Cell Rep 26: 1378-1388 e1373, 2019). These findings led us to hypothesize that identifying proteins sensitive to activity deprivation and/or FMRP expression could reveal pathways required for or modified by homeostatic plasticity. Here, we report an unbiased quantitative mass spectrometry used to quantify steady-state proteome changes following chronic activity deprivation in wild type and Fmr1−/y cortical neurons. Proteome hits responsive to both activity deprivation and the Fmr1−/y genotype were significantly annotated to mitochondria. We found an increased number of mitochondria annotated proteins whose expression was sensitive to activity deprivation in Fmr1−/y cortical neurons as compared to wild type neurons. These findings support a novel role of FMRP in attenuating mitochondrial proteome modifications induced by activity deprivation. The online version contains supplementary material available at 10.1186/s13041-021-00783-w.
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影响因子：
16.2
作者：
Hengen KB;Lambo ME;Van Hooser SD;Katz DB;Turrigiano GG
通讯作者：
Turrigiano GG
影响因子：
14.9
作者：
Kuleshov MV;Jones MR;Rouillard AD;Fernandez NF;Duan Q;Wang Z;Koplev S;Jenkins SL;Jagodnik KM;Lachmann A;McDermott MG;Monteiro CD;Gundersen GW;Ma'ayan A
通讯作者：
Ma'ayan A
影响因子：
3.7
作者：
D'Antoni, Simona;de Bari, Lidia;Catania, Maria Vincenza
通讯作者：
Catania, Maria Vincenza
DOI：
10.1093/bioinformatics/btp101
发表时间：
2009-04-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Bindea G;Mlecnik B;Hackl H;Charoentong P;Tosolini M;Kirilovsky A;Fridman WH;Pagès F;Trajanoski Z;Galon J
通讯作者：
Galon J
DOI：
10.1523/jneurosci.3077-12.2012
发表时间：
2012-09-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Blackman MP;Djukic B;Nelson SB;Turrigiano GG
通讯作者：
Turrigiano GG