The immunology of asymptomatic SARS-CoV-2 infection: what are the key questions?
The immunology of asymptomatic SARS-CoV-2 infection: what are the key questions?
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DOI：
10.1038/s41577-021-00631-x
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Altmann DM
中科院分区：
文献类型：
--
作者：
Boyton RJ;Altmann DM
COVID-19大流行期间的一个重要挑战是了解无症状疾病及其可能成为传播源的程度。由于无症状疾病的定义是难以筛查的，因此对COVID-19谱的这一方面缺乏明确性。研究已经考虑了无症状疾病的患病率是否由年龄、人口统计学、病毒载量、脱落持续时间以及免疫力的大小或持久性的差异决定。很明显，无症状感染期间获得性免疫被强烈激活，但T细胞和抗体反应的一些特征可能与有症状疾病中的特征不同。需要进一步明确的领域包括无症状疾病导致持续症状（长期COVID）的程度，以及提供后续保护所需的免疫启动的质量、数量和持久性。无症状COVID-19患者可传播病毒，并可能面临长期患病的风险。在这篇进展文章中，博伊顿和Altman介绍了目前对无症状SARS-CoV-2感染的免疫反应的见解，并讨论了无症状疾病与公共卫生策略的相关性。
An important challenge during the COVID-19 pandemic has been to understand asymptomatic disease and the extent to which this may be a source of transmission. As asymptomatic disease is by definition hard to screen for, there is a lack of clarity about this aspect of the COVID-19 spectrum. Studies have considered whether the prevalence of asymptomatic disease is determined by differences in age, demographics, viral load, duration of shedding, and magnitude or durability of immunity. It is clear that adaptive immunity is strongly activated during asymptomatic infection, but some features of the T cell and antibody response may differ from those in symptomatic disease. Areas that need greater clarity include the extent to which asymptomatic disease leads to persistent symptoms (long COVID), and the quality, quantity and durability of immune priming required to confer subsequent protection. Individuals with asymptomatic COVID-19 can transmit the virus and may be at risk of long-term disease. In this Progress article, Boyton and Altman present current insights into immune responses in asymptomatic SARS-CoV-2 infection and discuss the relevance of asymptomatic disease for public health strategies.
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DOI：
10.1093/cid/ciab172
发表时间：
2021-12-16
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
den Hartog G;Vos ERA;van den Hoogen LL;van Boven M;Schepp RM;Smits G;van Vliet J;Woudstra L;Wijmenga-Monsuur AJ;van Hagen CCE;Sanders EAM;de Melker HE;van der Klis FRM;van Binnendijk RS
通讯作者：
van Binnendijk RS
影响因子：
32.4
作者：
Jarjour NN;Masopust D;Jameson SC
通讯作者：
Jameson SC
影响因子：
24.8
作者：
Goel RR;Apostolidis SA;Painter MM;Mathew D;Pattekar A;Kuthuru O;Gouma S;Hicks P;Meng W;Rosenfeld AM;Dysinger S;Lundgreen KA;Kuri-Cervantes L;Adamski S;Hicks A;Korte S;Oldridge DA;Baxter AE;Giles JR;Weirick ME;McAllister CM;Dougherty J;Long S;D'Andrea K;Hamilton JT;Betts MR;Luning Prak ET;Bates P;Hensley SE;Greenplate AR;Wherry EJ
通讯作者：
Wherry EJ
影响因子：
56.9
作者：
Jones, Terry C.;Biele, Guido;Muhlemann, Barbara;Veith, Talitha;Schneider, Julia;Beheim-Schwarzbach, Joern;Bleicker, Tobias;Tesch, Julia;Schmidt, Marie Luisa;Sander, Leif Erik;Kurth, Florian;Menzel, Peter;Schwarzer, Rolf;Zuchowski, Marta;Hofmann, Joerg;Krumbholz, Andi;Stein, Angela;Edelmann, Anke;Corman, Victor Max;Drosten, Christian
通讯作者：
Drosten, Christian
中国武汉近一千万居民的锁骨后SARS-COV-2核酸筛查。
影响因子：
16.6
作者：
Cao S;Gan Y;Wang C;Bachmann M;Wei S;Gong J;Huang Y;Wang T;Li L;Lu K;Jiang H;Gong Y;Xu H;Shen X;Tian Q;Lv C;Song F;Yin X;Lu Z
通讯作者：
Lu Z